Andreollo Nelson Adami, Santos Elisvânia Freitas dos, Araújo Marina Rachel, Lopes Luiz Roberto
Laboratory of Enzymology and Experimental Carcinogenesis, Faculty of Medical Sciences, State University of Campinas, Campinas, SP, Brazil.
Arq Bras Cir Dig. 2012 Jan-Mar;25(1):49-51. doi: 10.1590/s0102-67202012000100011.
Millions of mice are used annually in research and teaching. The exact relationship between age of the animals compared with the age of humans is still subject to discussion and controversy.
Literature review analyzing the age of rats in comparison with men age.
Were reviewed the existing publications on the subject contained in Medline / PUBMED, SciELO, The Cochrane Database of Systematic Reviews and Lilacs crossing the headings rats, experimental surgery and physiology.
Rats rapidly develop during childhood and become sexually mature at about six weeks old, but reach social maturity five to six months later. In adulthood, every month of the animal is approximately equivalent to 2.5 human years. Several authors performed experimental studies in rats and estimated 30 days of human life for every day life of the animal.
The differences in anatomy, physiology, development and biological phenomena must be taken into consideration when analyzing the results of any research in rats when age is a crucial factor. Special care is necessary to be taken when the intention is to produce correlation with human life. For this, special attention is needed to verify the phase in days of the animal and its correlation with age in years of humans.
每年有数以百万计的小鼠用于研究和教学。动物年龄与人类年龄之间的确切关系仍存在争议。
通过文献综述分析大鼠年龄与人类年龄的比较。
检索了Medline / PUBMED、SciELO、Cochrane系统评价数据库和Lilacs中关于该主题的现有出版物，检索词包括大鼠、实验手术和生理学。
大鼠在幼年时期发育迅速，约六周龄时性成熟，但社交成熟则在五到六个月后。成年后，动物的每个月大约相当于人类的2.5年。几位作者对大鼠进行了实验研究，并估计动物的每一天相当于人类的30天寿命。
在分析大鼠的任何研究结果时，如果年龄是一个关键因素，必须考虑到解剖学、生理学、发育和生物学现象的差异。当意图是与人类生活建立关联时，需要特别小心。为此，需要特别注意核实动物的日龄阶段及其与人类年龄的相关性。
