Laboratory of Genetic Disease and Perinatal Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China.
Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China.
Fertil Steril. 2015 May;103(5):1346-54. doi: 10.1016/j.fertnstert.2015.02.024. Epub 2015 Mar 23.
To determine the relationships among the inflammatory index, intrinsic oxidation levels, lipid and apolipoprotein (apo)A-I concentrations of high-density lipoprotein (HDL), and polycystic ovary syndrome (PCOS).
Cross-sectional study.
University hospital.
PATIENT(S): A total of 425 patients with PCOS and 441 control women were included.
INTERVENTION(S): None.
MAIN OUTCOME MEASURE(S): The HDL inflammatory index (HII) was determined using a cell-free fluorometric assay. Intrinsic HDL oxidation levels, HDL-free cholesterol, HDL-cholesterol ester, HDL-triglyceride, serum apoA-I, and malondialdehyde levels were also measured.
RESULT(S): The mean HII value and the frequency of HII ≥1 were significantly higher in the PCOS group (0.77 ± 0.54, 27.1%) than in the control group (0.53 ± 0.37, 8.4%). These values were also higher in each of the 4 PCOS phenotypes based on the Rotterdam criteria than in the controls, and higher in patients with hyperandrogenism (HA) + oligo- and/or anovulation (OA) phenotype than in those with OA + polycystic ovary (PCO) phenotype. Furthermore, patients with PCOS with OA + PCO had lower malondialdehyde and intrinsic HDL oxidation levels compared with those with HA. Multivariate regression analysis demonstrated that PCOS, HDL-cholesterol ester, and E2 levels were the main predictors of HII value.
CONCLUSION(S): The impairment of HDL antioxidant/anti-inflammatory function in PCOS is related to HA status, increased oxidative stress, and abnormalities in HDL components and thus may contribute to PCOS pathogenesis and increase the risks of future cardiovascular diseases.
探讨炎症指数与高密度脂蛋白（HDL）固有氧化水平、脂质和载脂蛋白（apo）A-I 浓度及多囊卵巢综合征（PCOS）之间的关系。
横断面研究。
大学医院。
共纳入 425 例 PCOS 患者和 441 例对照女性。
无。
采用无细胞荧光法测定 HDL 炎症指数（HII）。还测定了 HDL 固有氧化水平、HDL 游离胆固醇、HDL 胆固醇酯、HDL 甘油三酯、血清 apoA-I 和丙二醛水平。
PCOS 组的平均 HII 值和 HII≥1 的频率（0.77±0.54，27.1%）明显高于对照组（0.53±0.37，8.4%）。根据鹿特丹标准，每种 PCOS 表型的这些值均高于对照组，且高雄激素血症（HA）+排卵障碍和/或闭经（OA）表型患者高于 OA+多囊卵巢（PCO）表型患者。此外，OA+PCO 表型的 PCOS 患者的丙二醛和 HDL 固有氧化水平低于 HA 患者。多元回归分析表明，PCOS、HDL 胆固醇酯和 E2 水平是 HII 值的主要预测因子。
PCOS 中 HDL 抗氧化/抗炎功能的损害与 HA 状态、氧化应激增加以及 HDL 成分异常有关，可能导致 PCOS 发病机制，并增加未来发生心血管疾病的风险。
