[酒精性肝损伤中肝细胞中间丝细胞骨架的变化]
[Changes in the intermediate filament cytoskeleton of liver cells in alcoholic liver injury].
作者信息
Denk H, Lackinger E
出版信息
Wien Klin Wochenschr. 1985 Apr 12;97(8):354-8.
PMID:2581375
Abstract
Mallory bodies are a morphological key feature of severe alcoholic liver cell injury (alcoholic hepatitis) and the morphological expression of dysregulation and derangement of the intermediate filament cytoskeleton of the hepatocyte. Their pathogenesis is still unclear. Studies on Mallory body formation may not only help to elucidate the mechanisms of liver cell injury associated with alcoholic hepatitis, but may also contribute to our understanding of the regulation and function of the intermediate filament cytoskeleton.
摘要
马洛里小体是严重酒精性肝细胞损伤（酒精性肝炎）的一个形态学关键特征，也是肝细胞中间丝细胞骨架失调和紊乱的形态学表现。其发病机制仍不清楚。对马洛里小体形成的研究不仅可能有助于阐明与酒精性肝炎相关的肝细胞损伤机制，还可能有助于我们理解中间丝细胞骨架的调节和功能。
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[Changes in the intermediate filament cytoskeleton of liver cells in alcoholic liver injury].[酒精性肝损伤中肝细胞中间丝细胞骨架的变化]
Wien Klin Wochenschr. 1985 Apr 12;97(8):354-8.
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7
Pathology of cytoskeleton of liver cells: demonstration of mallory bodies (alcoholic hyalin) in murine and human hepatocytes by immunofluorescence microscopy using antibodies to cytokeratin polypeptides from hepatocytes.肝细胞细胞骨架病理学：使用针对肝细胞细胞角蛋白多肽的抗体，通过免疫荧光显微镜在小鼠和人类肝细胞中显示马洛里小体（酒精性透明小体）
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