Sherman Kerry, Shaw Laura-Kate, Champion Katrina, Caldeira Fernanda, McCaskill Margaret
Centre for Emotional Health, Macquarie University, Sydney, Australia.
Westmead Breast Cancer Institute, Westmead Hospital, Sydney, Australia.
J Behav Med. 2015 Oct;38(5):706-14. doi: 10.1007/s10865-015-9630-9. Epub 2015 Mar 27.
The effect of disease-specific cognitions on interest in clinic-based and direct-to-consumer (DTC) genetic testing was assessed. Participants (N = 309) responded to an online hypothetical scenario and received genetic testing-related messages that varied by risk probability (25, 50, 75 %) and disease type (Alzheimer's disease vs. Type 2 Diabetes). Post-manipulation interest increased for both testing types, but was greater for clinic-based testing. Interest was greater for Type 2 Diabetes than for Alzheimer's disease, the latter perceived as more severe and likely, and less treatable and preventable. For DTC testing only, participants allocated to the high risk condition (75 %) had greater testing interest than those in the low (25 %) category. DTC testing is perceived as a viable, but less preferred, option compared with clinic-based testing. Particularly when considering DTC genetic testing, there is a need to emphasize subjective disease-related perceptions, including risk probability.
评估了特定疾病认知对基于诊所和直接面向消费者（DTC）基因检测兴趣的影响。参与者（N = 309）对一个在线假设情景做出反应，并收到了因风险概率（25%、50%、75%）和疾病类型（阿尔茨海默病与2型糖尿病）而异的基因检测相关信息。两种检测类型在操作后的兴趣都有所增加，但基于诊所的检测兴趣更高。2型糖尿病的兴趣高于阿尔茨海默病，后者被认为更严重、更有可能发生，且更难治疗和预防。仅对于DTC检测，被分配到高风险条件（75%）的参与者比低风险（25%）类别的参与者有更高的检测兴趣。与基于诊所的检测相比，DTC检测被视为一种可行但不太受欢迎的选择。特别是在考虑DTC基因检测时，有必要强调与疾病相关的主观认知，包括风险概率。
