Department of Neurophysiology, Nencki Institute of Experimental Biology, Polish Academy of Sciences Warszawa, Poland ; Department of Biophysics, Warsaw University of Life Sciences Warszawa, Poland.
Department of Molecular and Cellular Neurobiology, Nencki Institute of Experimental Biology, Polish Academy of Sciences Warszawa, Poland ; Unidad Ciclotron, Centro Nacional de Aceleradores (Universidad de Sevilla - CSIC - Junta de Andalucia) Sevilla, Spain.
Front Cell Neurosci. 2015 Mar 11;9:73. doi: 10.3389/fncel.2015.00073. eCollection 2015.
It has been shown that matrix metalloproteinase 9 (MMP-9) is required for synaptic plasticity, learning and memory. In particular, MMP-9 involvement in long-term potentiation (LTP, the model of synaptic plasticity) in the hippocampus and prefrontal cortex has previously been demonstrated. Recent data suggest the role of MMP-9 in amygdala-dependent learning and memory. Nothing is known, however, about its physiological correlates in the specific pathways in the amygdala. In the present study we show that LTP in the basal and central but not lateral amygdala (LA) is affected by MMP-9 knock-out. The MMP-9 dependency of LTP was confirmed in brain slices treated with a specific MMP-9 inhibitor. The results suggest that MMP-9 plays different roles in synaptic plasticity in different nuclei of the amygdala.
已有研究表明，基质金属蛋白酶 9（MMP-9）是突触可塑性、学习和记忆所必需的。特别是，MMP-9 参与了海马体和前额叶皮层中的长时程增强（LTP，突触可塑性的模型），这一点以前已经得到证实。最近的数据表明 MMP-9 在杏仁核依赖的学习和记忆中起作用。然而，在杏仁核的特定通路中，关于 MMP-9 的生理相关性，目前还知之甚少。在本研究中，我们发现基底核和中央杏仁核（CEA）中的 LTP 受到 MMP-9 基因敲除的影响，但外侧杏仁核（LA）中的 LTP 不受影响。在使用特定的 MMP-9 抑制剂处理的脑片中证实了 LTP 对 MMP-9 的依赖性。这些结果表明，MMP-9 在杏仁核不同核团中的突触可塑性中发挥不同的作用。
