立体选择性阴极合成 8-取代的（1R,3R,4S）-薄荷基胺。
Stereoselective cathodic synthesis of 8-substituted (1R,3R,4S)-menthylamines.
机构信息
Institut für Organische Chemie, Johannes Gutenberg-Universität Mainz, Duesbergweg 10-14, 55128 Mainz, Germany.
出版信息
Beilstein J Org Chem. 2015 Feb 27;11:294-301. doi: 10.3762/bjoc.11.34. eCollection 2015.
Abstract
The electrochemical generation of menthylamines from the corresponding menthone oximes equipped with an additional substituent in position 8 is described. Due to 1,3-diaxial interactions a pronounced diastereoselectivity for the menthylamines is found.
摘要
本文描述了在 8 位带有额外取代基的相应薄荷酮肟的基础上电化学生成薄荷胺。由于 1,3-双轴向相互作用，发现薄荷胺具有显著的非对映选择性。
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