Ana I Flores, Gonzalo J Gómez-Gómez, Ángeles Masedo-González, M Pilar Martínez-Montiel, Servicio de Aparato Digestivo, Hospital 12 de Octubre, Avda. de Córdoba, 28041 Madrid, Spain.
World J Stem Cells. 2015 Mar 26;7(2):343-51. doi: 10.4252/wjsc.v7.i2.343.
Inflammatory bowel diseases are inflammatory, chronic and progressive diseases of the intestinal tract for which no curative treatment is available. Research in other fields with stem cells of different sources and with immunoregulatory cells (regulatory T-lymphocytes and dendritic T-cells) opens up new expectations for their use in these diseases. The goal for stem cell-based therapy is to provide a permanent cure. To achieve this, it will be necessary to obtain a cellular product, original or genetically modified, that has a high migration capacity and homes into the intestine, has high survival after transplantation, regulates the immune reaction while not being visible to the patient's immune system, and repairs the injured tissue.
炎症性肠病是一种炎症性、慢性和进行性的肠道疾病，目前尚无治愈方法。在其他领域使用不同来源的干细胞和免疫调节细胞（调节性 T 淋巴细胞和树突状 T 细胞）的研究为它们在这些疾病中的应用带来了新的希望。基于干细胞的治疗的目标是提供永久性的治愈。为了实现这一目标，有必要获得具有高迁移能力和归巢到肠道的原始或基因修饰的细胞产物，具有高移植后存活率，在不被患者免疫系统识别的情况下调节免疫反应，以及修复受损组织。
