Hye-Ryung Choi, Sang-Young Byun, Soon-Hyo Kwon, Kyoung-Chan Park, Department of Dermatology, Seoul National University Bundang Hospital, Seongnam-si, Gyounggi-do 463-707, South Korea.
World J Stem Cells. 2015 Mar 26;7(2):495-501. doi: 10.4252/wjsc.v7.i2.495.
Within the epidermis and dermis of the skin, cells secrete and are surrounded by the extracellular matrix (ECM), which provides structural and biochemical support. The ECM of the epidermis is the basement membrane, and collagen and other dermal components constitute the ECM of the dermis. There is significant variation in the composition of the ECM of the epidermis and dermis, which can affect "cell to cell" and "cell to ECM" interactions. These interactions, in turn, can influence biological responses, aging, and wound healing; abnormal ECM signaling likely contributes to skin diseases. Thus, strategies for manipulating cell-ECM interactions are critical for treating wounds and a variety of skin diseases. Many of these strategies focus on epidermal stem cells, which reside in a unique niche in which the ECM is the most important component; interactions between the ECM and epidermal stem cells play a major role in regulating stem cell fate. As they constitute a major portion of the ECM, it is likely that integrins and type IV collagens are important in stem cell regulation and maintenance. In this review, we highlight recent research-including our previous work-exploring the role that the ECM and its associated components play in shaping the epidermal stem cell niche.
在皮肤的表皮和真皮中，细胞分泌并被细胞外基质（ECM）包围，ECM 提供结构和生化支持。表皮的 ECM 是基底膜，而胶原蛋白和其他真皮成分构成真皮的 ECM。表皮和真皮的 ECM 组成有很大的差异，这会影响“细胞间”和“细胞与 ECM 间”的相互作用。这些相互作用反过来又会影响生物反应、衰老和伤口愈合；异常的 ECM 信号可能导致皮肤疾病。因此，操纵细胞-ECM 相互作用的策略对于治疗伤口和各种皮肤疾病至关重要。这些策略中的许多都集中在表皮干细胞上，表皮干细胞存在于一个独特的微环境中，其中 ECM 是最重要的成分；ECM 与表皮干细胞之间的相互作用在调节干细胞命运方面起着重要作用。由于它们构成了 ECM 的主要部分，整合素和 IV 型胶原很可能在干细胞的调节和维持中发挥重要作用。在这篇综述中，我们强调了最近的研究，包括我们之前的工作，探讨了 ECM 及其相关成分在塑造表皮干细胞生态位中的作用。
