Kwon Soon-Hyo, Park Kyoung-Chan
Department of Dermatology, Kyung Hee University Hospital at Gang-dong, Kyung Hee University School of Medicine, Seoul 05278, Korea.
Seoul National University College of Medicine, Department of Dermatology, Seoul National University Bundang Hospital, Gyeonggi 13620, Korea.
Antioxidants (Basel). 2020 Oct 7;9(10):958. doi: 10.3390/antiox9100958.
Antioxidants may modulate the microenvironment of epidermal stem cells by reducing the production of reactive oxygen species or by regulating the expression of extracellular matrix protein. The extracellular membrane is an important component of the stem cell niche, and microRNAs regulate extracellular membrane-mediated basal keratinocyte proliferation. In this narrative review, we will discuss several antioxidants such as ascorbic acid, plant extracts, peptides and hyaluronic acid, and their effect on the epidermal stem cell niche and the proliferative potential of interfollicular epidermal stem cells in 3D skin equivalent models.
抗氧化剂可通过减少活性氧的产生或调节细胞外基质蛋白的表达来调节表皮干细胞的微环境。细胞外膜是干细胞生态位的重要组成部分，而微小RNA调节细胞外膜介导的基底角质形成细胞增殖。在这篇叙述性综述中，我们将讨论几种抗氧化剂，如抗坏血酸、植物提取物、肽和透明质酸，以及它们在三维皮肤等效模型中对表皮干细胞生态位和毛囊间表皮干细胞增殖潜能的影响。
