Bhuin Tanmay, Roy Jagat Kumar
Cell and Developmental Biology Unit, Department of Zoology, The University of Burdwan, Golapbag-713104, India.
Cytogenetics Laboratory, Department of Zoology, Banaras Hindu University, Varanasi-221 005, India.
Int J Mol Cell Med. 2015 Winter;4(1):1-8.
Membrane/protein trafficking in the secretory/biosynthetic and endocytic pathways is mediated by vesicles. Vesicle trafficking in eukaryotes is regulated by a class of small monomeric GTPases: the Rab protein family. Rab proteins represent the largest branch of the Ras superfamily GTPases, and have been concerned in a variety of intracellular vesicle trafficking and different intracellular signalling pathways. Rab11 (a subfamily of the Ypt/Rab gene family), an evolutionarily conserved ubiquitously expressed subfamily of Rab GTPases, has been implicated in regulating vesicular trafficking through the recycling of endosomes. Rabs have been grouped into different subfamilies based on the distinct unambiguous sequence motifs. Three members: Rab11a, Rab11b and Rab25 make up the Rab11 GTPase subfamily. In this review article, we describe an overview over Rab11 subfamily with a brief structural aspect and its roles in implicating different disease progression.
膜/蛋白质在分泌/生物合成和内吞途径中的运输由囊泡介导。真核生物中的囊泡运输由一类小的单体GTP酶调节：Rab蛋白家族。Rab蛋白是Ras超家族GTP酶中最大的分支，参与多种细胞内囊泡运输和不同的细胞内信号通路。Rab11（Ypt/Rab基因家族的一个亚家族）是Rab GTP酶中进化保守且普遍表达的亚家族，通过内体循环参与调节囊泡运输。根据不同的明确序列基序，Rab被分为不同的亚家族。三个成员：Rab11a、Rab11b和Rab25组成了Rab11 GTP酶亚家族。在这篇综述文章中，我们概述了Rab11亚家族，简要介绍了其结构方面以及在不同疾病进展中的作用。
