Ishibashi T, Miki K, Sorgente N, Patterson R, Ryan S J
Arch Ophthalmol. 1985 May;103(5):708-11. doi: 10.1001/archopht.1985.01050050100026.
To elucidate the role of inflammation in the occurrence of experimental subretinal neovascularization caused by high-intensity laser photocoagulation, we investigated the effects of vitreal infusion of steroids on laser lesions in a primate model. Dexamethasone, with or without triamcinolone, was infused continuously for two weeks through an indwelling cannula system. The animals were followed up clinically for up to eight weeks. The frequency of subretinal neovascularization in the steroid-treated animals was significantly lower than that in a control group of untreated animals. Although steroids have multiple effects, these results suggest that the inflammatory response, possibly macrophage infiltration, may plan an important role in the occurrence of subretinal neovascularization in our experimental model.
为阐明炎症在高强度激光光凝所致实验性视网膜下新生血管形成中的作用，我们在灵长类动物模型中研究了玻璃体注射类固醇对激光损伤的影响。地塞米松联合或不联合曲安奈德，通过留置套管系统连续注射两周。对动物进行了长达八周的临床随访。接受类固醇治疗的动物视网膜下新生血管形成的频率显著低于未治疗的对照组动物。尽管类固醇有多种作用，但这些结果表明，炎症反应，可能是巨噬细胞浸润，在我们的实验模型中视网膜下新生血管形成过程中可能起重要作用。
