Ran Jisheng, Hu Yejun, Zheng Zefeng, Zhu Ting, Zheng Huawei, Jing Yibiao, Xu Kan
Department of Orthopedic Surgery, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
PLoS One. 2015 Mar 27;10(3):e0121816. doi: 10.1371/journal.pone.0121816. eCollection 2015.
Lumbar disc removal is currently the standard treatment for lumbar disc herniation. No consensus has been achieved whether aggressive disc resection with curettage (discectomy) versus conservative removal of the offending disc fragment alone (sequestrectomy) provides better outcomes. This study aims to compare the reherniation rate and clinical outcomes between discectomy and sequestrectomy by literature review and a meta-analysis.
A systematic search of PubMed, Medline, Embase and the Cochrane Library was performed up to June 1, 2014. Outcomes of interest assessing the two techniques included demographic and clinical baseline characteristics, perioperative variables, complications, recurrent herniation rate and post-operative functional outcomes.
Twelve eligible trials evaluating discectomy vs sequestrectomy were identified including one randomized controlled study, five prospective and six retrospective comparative studies. By contrast to discectomy, sequestrectomy was associated with significantly less operative time (p<0.001), lower visual analogue scale (VAS) for low back pain (p<0.05), less post-operative analgesic usage (p<0.05) and better patients' satisfaction (p<0.05). Recurrent herniation rate, reoperation rate, intraoperative blood loss, hospitalization duration and VAS for sciatica were without significant difference.
According to our pooled data, sequestrectomy entails equivalent reherniation rate and complications compared with discectomy but maintains a lower incidence of recurrent low back pain and higher satisfactory rate. High-quality prospective randomized controlled trials are needed to firmly assess these two procedures.
腰椎间盘切除术是目前治疗腰椎间盘突出症的标准方法。对于积极的椎间盘刮除切除术(椎间盘切除术)与仅保守切除突出的椎间盘碎片(髓核摘除术)哪种方法能带来更好的疗效,目前尚未达成共识。本研究旨在通过文献综述和荟萃分析比较椎间盘切除术和髓核摘除术的再突出率及临床疗效。
截至2014年6月1日,对PubMed、Medline、Embase和Cochrane图书馆进行了系统检索。评估这两种技术的相关结果包括人口统计学和临床基线特征、围手术期变量、并发症、复发性突出率和术后功能结果。
共确定了12项评估椎间盘切除术与髓核摘除术的合格试验,包括1项随机对照研究、5项前瞻性研究和6项回顾性比较研究。与椎间盘切除术相比,髓核摘除术的手术时间明显更短(p<0.001),下腰痛视觉模拟评分(VAS)更低(p<0.05),术后镇痛药物使用更少(p<0.05),患者满意度更高(p<0.05)。复发性突出率、再次手术率、术中失血量、住院时间和坐骨神经痛VAS无显著差异。
根据我们汇总的数据,髓核摘除术与椎间盘切除术相比,再突出率和并发症相当,但复发性下腰痛的发生率更低,满意度更高。需要高质量的前瞻性随机对照试验来确切评估这两种手术方法。