Serghini Meriem, Wechtati Marwa, Boubaker Jalel, Filali Azza
Tunis Med. 2014 Aug-Sep;92(8-9):551-5.
Diet is thought to have an important role in the etiopathogenesis of Crohn's disease. In the other hand, Crohn's disease is frequently associated with nutritional deficiencies probably as result of disease activity and poor oral intake.
To investigate the dietary intake in patients with Crohn's disease in comparison with matched population controls and to assess the correlation between the results of the dietary enquete, nutritional status and disease activity.
We conducted a prospective case control study in patients with Crohn's disease and matched controls. All subjects were evaluated in respect of dietary intake (based on "NUTISTAR" logiciel) and nutritional status.
We studied 23 patients and 23 controls. There was no statistical difference between patients and controls according to the proportion of carbohydrates, fat and protein intakes. Energy intakes were significantly lower in patients with Crohn's disease (1991 + 678 kcal/j) compared to controls (2537 + 345 kcal/j) (p=0.007) ; and in active disease (1353 + 308 kcal/j) compared to inactive disease patients (2481 + 415 kcal/j) (p<0.0001). In Crohn's disease patients, correlation study showed that energy intakes were correlated with CDAI (p<0.0001 ; r = - 0.74) and BMI (p=0.03 ; r = 0.45).
In Crohn's disease, an inadequate dietary intake is correlated with nutritional status and disease activity.
饮食被认为在克罗恩病的发病机制中起重要作用。另一方面，克罗恩病常伴有营养缺乏，这可能是疾病活动和口服摄入量低的结果。
与匹配的人群对照组相比，调查克罗恩病患者的饮食摄入量，并评估饮食调查结果、营养状况和疾病活动之间的相关性。
我们对克罗恩病患者和匹配的对照组进行了一项前瞻性病例对照研究。所有受试者均就饮食摄入量（基于“NUTISTAR”软件）和营养状况进行了评估。
我们研究了23例患者和23例对照。根据碳水化合物、脂肪和蛋白质摄入量的比例，患者和对照之间没有统计学差异。克罗恩病患者的能量摄入量（1991 + 678千卡/天）显著低于对照组（2537 + 345千卡/天）（p = 0.007）；与非活动期疾病患者（2481 + 415千卡/天）相比，活动期疾病患者的能量摄入量（1353 + 308千卡/天）更低（p < 0.0001）。在克罗恩病患者中，相关性研究表明能量摄入量与CDAI相关（p < 0.0001；r = - 0.74）和BMI相关（p = 0.03；r = 0.45）。
在克罗恩病中，饮食摄入不足与营养状况和疾病活动相关。
