Uysal E B, Tuzcu N, Sancakdar E, Güven A S, Akkar I, Deveci K, Kaya A
Department of Microbiology, Cumhuriyet University, Sivas, Turkey.
J Vector Borne Dis. 2015 Mar;52(1):36-9.
BACKGROUND & OBJECTIVES: Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne viral disease, causing severe viral hemorrhagic fever outbreaks. This study aimed at determining the serum vitamin D levels and investigated the association between Crimean-Congo hemorrhagic fever (CCHF) and serum vitamin D levels in children with CCHF.
A total of 45 children aged between 5 and 15 yr, viz. 15 healthy control (HC) and 30 pediatric patients diagnosed with CCHF with real-time polymerase chain reaction (PCR) (patient group) were selected for the study.
Analysis of the blood serum samples taken from the said individuals revealed that vitamin D, parathyroid hormone and calcium levels of the patients and the control groups were statistically different.
INTERPRETATION & CONCLUSION: It was found that the serum vitamin D levels of the pediatric patients with CCHF were lower when compared to those of the controls, and that a low vitamin D level could negatively affect the reaction of the body to infections in children having CCHF.
克里米亚-刚果出血热（CCHF）是一种蜱传病毒性疾病，可引发严重的病毒性出血热疫情。本研究旨在测定血清维生素D水平，并探讨克里米亚-刚果出血热（CCHF）与患CCHF儿童血清维生素D水平之间的关联。
本研究共选取了45名年龄在5至15岁之间的儿童，即15名健康对照者（HC）和30名经实时聚合酶链反应（PCR）确诊为CCHF的儿科患者（患者组）。
对上述个体采集的血清样本分析显示，患者组和对照组的维生素D、甲状旁腺激素和钙水平存在统计学差异。
研究发现，患CCHF的儿科患者血清维生素D水平低于对照组，且低维生素D水平可能会对患CCHF儿童的机体感染反应产生负面影响。
