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从一种海洋被囊动物中分离出的青霉属真菌CYE-87的化合物鉴定及生物活性

Identification and bioactivity of compounds from the fungus Penicillium sp. CYE-87 isolated from a marine tunicate.

作者信息

Shaala Lamiaa A, Youssef Diaa T A

机构信息

Natural Products Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia.

Suez Canal University Hospital, Suez Canal University, Ismailia 51522, Egypt.

出版信息

Mar Drugs. 2015 Mar 25;13(4):1698-709. doi: 10.3390/md13041698.

DOI:10.3390/md13041698
PMID:25815893
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4413182/
Abstract

In the course of our continuous interest in identifying bioactive compounds from marine microbes, we have investigated a tunicate-derived fungus, Penicillium sp. CYE-87. A new compound with the 1,4-diazepane skeleton, terretrione D (2), together with the known compounds, methyl-2-([2-(1H-indol-3-yl)ethyl]carbamoyl)acetate (1), tryptamine (3), indole-3-carbaldehyde (4), 3,6-diisobutylpyrazin-2(1H)-one (5) and terretrione C (6), were isolated from Penicillium sp. CYE-87. The structures of the isolated compounds were established by spectral analysis, including 1D (1H, 13C) and 2D (COSY, multiplicity edited-HSQC and HMBC) NMR and HRESIMS, as well as comparison of their NMR data with those in the literature. The compounds were evaluated for their antimigratory activity against the human breast cancer cell line (MDA-MB-231) and their antiproliferation activity against HeLa cells. Compounds 2 and 6 showed significant antimigratory activity against MDA-MB-231, as well as antifungal activity against C. albicans.

摘要

在我们持续致力于从海洋微生物中鉴定生物活性化合物的过程中，我们研究了一种源自被囊动物的真菌——青霉菌CYE - 87。从青霉菌CYE - 87中分离出了一种具有1,4 - 二氮杂环庚烷骨架的新化合物土曲霉酮D（2），以及已知化合物甲基 - 2 - ([2 - (1H - 吲哚 - 3 - 基)乙基]氨基甲酰基)乙酸酯（1）、色胺（3）、吲哚 - 3 - 甲醛（4）、3,6 - 二异丁基吡嗪 - 2(1H) - 酮（5）和土曲霉酮C（6）。通过光谱分析确定了分离出的化合物的结构，包括一维（1H、13C）和二维（COSY、多重性编辑 - HSQC和HMBC）核磁共振以及高分辨电喷雾电离质谱，还将它们的核磁共振数据与文献中的数据进行了比较。对这些化合物针对人乳腺癌细胞系（MDA - MB - 231）的抗迁移活性以及针对HeLa细胞的抗增殖活性进行了评估。化合物2和6对MDA - MB - 231显示出显著的抗迁移活性，同时对白色念珠菌具有抗真菌活性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1661/4413182/b4d202a901e9/marinedrugs-13-01698-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1661/4413182/5a161dedc11c/marinedrugs-13-01698-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1661/4413182/6082be3b58ac/marinedrugs-13-01698-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1661/4413182/b4d202a901e9/marinedrugs-13-01698-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1661/4413182/5a161dedc11c/marinedrugs-13-01698-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1661/4413182/6082be3b58ac/marinedrugs-13-01698-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1661/4413182/b4d202a901e9/marinedrugs-13-01698-g003.jpg

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