来自深海真菌短密青霉DFFSCS025的短密酰胺和麦考酚酸衍生物
Brevianamides and Mycophenolic Acid Derivatives from the Deep-Sea-Derived Fungus Penicillium brevicompactum DFFSCS025.
作者信息
Xu Xinya, Zhang Xiaoyong, Nong Xuhua, Wang Jie, Qi Shuhua
机构信息
Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, China.
出版信息
Mar Drugs. 2017 Feb 17;15(2):43. doi: 10.3390/md15020043.
Four new compounds (-), including two brevianamides and two mycochromenic acid derivatives along with six known compounds were isolated from the deep-sea-derived fungus DFFSCS025. Their structures were elucidated by spectroscopic analysis. Moreover, the absolute configurations of and were determined by quantum chemical calculations of the electronic circular dichroism (ECD) spectra. Compound showed moderate cytotoxicity against human colon cancer HCT116 cell line with IC value of 15.6 μM. In addition, and had significant antifouling activity against larval settlement with EC values of 13.7 and 22.6 μM, respectively. The NMR data of , , and were assigned for the first time.
从深海来源的真菌DFFSCS025中分离出4个新化合物（-），包括2个短柄酰胺和2个霉菌色原酸衍生物以及6个已知化合物。通过光谱分析阐明了它们的结构。此外，通过电子圆二色（ECD）光谱的量子化学计算确定了 和 的绝对构型。化合物 对人结肠癌HCT116细胞系显示出中等细胞毒性，IC值为15.6 μM。此外， 和 对 幼虫附着具有显著的防污活性，EC值分别为13.7和22.6 μM。首次对 、 和 的核磁共振数据进行了归属。
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