[大鼠中代森锌和丙基硫氧嘧啶的致畸和致甲状腺肿活性]

[Teratogenic and goitrogenic activity of propineb and propylenethiourea in the rat].

作者信息

Vicari L, De Dominicis G, Vito M, Placida C, De Marinis E

出版信息

Boll Soc Ital Biol Sper. 1985 Feb 28;61(2):271-8.

Abstract

The teratogenic and goitrogenic effects of Propineb, dithiocarbamate pesticide and Propylenthiourea (PLTU), its metabolite and degradation product have been studied. The aim of this study was to show the possible correlation between the two activities. Female Sprague-Dawley rats were treated with Propineb and PLTU starting from 6th to 16th day of pregnancy. The functional state of maternal and foetal thyroid, the toxicity of products versus dams and embryotoxic and teratogenic effects were examined. The observed goitrogenic effect may be compared to that reported in the previous studies of the authors, if considering time of sacrifice. In fact, the lesion quickly rises and as rapidly regresses when treatment is stopped. The foetal thyroid has not been affected by the product administered to the dams. PLTU showed a clear teratogenic activity at doses that did not show any maternal toxicity (45 and 90 mg/k).

摘要

已对代森锌（一种二硫代氨基甲酸盐农药）及其代谢产物和降解产物丙硫氧嘧啶（PLTU）的致畸和致甲状腺肿作用进行了研究。本研究的目的是揭示这两种活性之间可能存在的相关性。从妊娠第6天至第16天，对雌性斯普拉格-道利大鼠用代森锌和PLTU进行处理。检测了母体和胎儿甲状腺的功能状态、产物对母鼠的毒性以及胚胎毒性和致畸作用。如果考虑处死时间，观察到的致甲状腺肿作用可与作者先前研究中报道的情况进行比较。事实上，当停止治疗时，病变迅速上升并同样迅速消退。给予母鼠的产物未对胎儿甲状腺产生影响。PLTU在未显示任何母体毒性的剂量（45和90毫克/千克）下表现出明显的致畸活性。