某些农药的长期影响研究。

Study on the long-term effects of some pesticides.

作者信息

Ivanova-Chemishanska L, Vergieva T, Antonov G, Mirkova E

出版信息

J Hyg Epidemiol Microbiol Immunol. 1980;24(3):295-302.

Abstract

The hygienic significance of the studies on pesticides from the aspect of their "long-term" effects upon the individual and the generations are emphasized. The basic methods and approaches used in the Laboratory of long-term effects with chemical etiology at the IHOH, Sofia, are discussed, namely for detecting the changes in gonads, reproduction and generation, embryotoxic and teratogenic effects, and changes in cardiovascular system. The results are discussed, namely: fundasol--the effect on gonads, generations, embryotoxic and teratogenic effects, changes in the cardiovascular system; endodan--changes in gonads, reproduction, embryotoxicity; basfungin--embryotoxic and teratogenic effects. All of these studies were performed for the purpose of threshold levels, establishment hygienic standardisation and prognosis of the potential risk for human.

摘要

强调了从农药对个体和后代的“长期”影响方面进行研究的卫生学意义。讨论了索非亚国际卫生与人口研究所化学病因长期影响实验室所采用的基本方法和途径，即用于检测性腺、生殖和代际变化、胚胎毒性和致畸作用以及心血管系统变化。对结果进行了讨论，即：丰索磷——对性腺、代际、胚胎毒性和致畸作用、心血管系统变化的影响；地虫磷——性腺、生殖、胚胎毒性的变化；谷仁乐生——胚胎毒性和致畸作用。所有这些研究都是为了确定阈值水平、建立卫生标准以及预测对人类的潜在风险。