在小鼠精子形态学试验中对二硫代氨基甲酸盐类农药丙森锌的评估。

Evaluation of Propineb, a dithiocarbamate pesticide, in the mouse-sperm morphology assay.

作者信息

Quinto I, De Marinis E

出版信息

Mutat Res. 1983 Dec;124(3-4):235-40. doi: 10.1016/0165-1218(83)90194-5.

Abstract

Propineb, a dithiocarbamate fungicide, was studied by using the sperm morphology assay in (C57BL6 male X C3H female) F1 mice. At all dose levels, no statistically significant increase in the percentage of sperm abnormalities was observed. Methyl methanesulfonate (MMS) and 2-acetylaminofluorene (2-AAF), which were tested as positive controls, induced a dose-effect-related increase in teratospermia.

摘要

代森锌，一种二硫代氨基甲酸盐类杀菌剂，通过在（C57BL6雄性×C3H雌性）F1小鼠中进行精子形态学检测进行研究。在所有剂量水平下，均未观察到精子异常百分比有统计学意义的增加。作为阳性对照进行测试的甲基磺酸甲酯（MMS）和2-乙酰氨基芴（2-AAF）诱导了与剂量效应相关的畸形精子症增加。