Kansas State University, College of Veterinary Medicine, Department of Anatomy and Physiology, 228 Coles Hall, Manhattan, KS 66506, USA.
Vet J. 2011 Jan;187(1):133-5. doi: 10.1016/j.tvjl.2009.09.022. Epub 2009 Oct 23.
The purpose of this study was to assess the pharmacokinetics of gabapentin in healthy greyhound dogs after single oral doses targeted at 10 and 20mg/kg PO. Six healthy greyhounds were enrolled (3 males, 3 females). Blood was obtained at predetermined times for the measurement of gabapentin plasma concentrations by liquid chromatography/mass spectrometry. Pharmacokinetic parameters were determined with computer software. The actual mean (and range) doses administered were 10.2 (9.1-12.0) mg/kg and 20.5 (18.2-24) mg/kg for the 10mg/kg and 20mg/kg targeted dose groups. The mean C(MAX) for the 10 and 20mg/kg groups were 8.54 and 13.22 microg/mL at 1.3 and 1.5h, and the terminal half-lives were 3.3 and 3.4h, respectively. The relative bioavailability of the 10mg/kg group was 1.13 compared to the 20mg/kg group. Gabapentin was rapidly absorbed and eliminated in dogs, indicating that frequent dosing is needed to maintain minimum targeted plasma concentrations.
本研究旨在评估单次口服 10 和 20mg/kg 剂量的加巴喷丁在健康灰狗犬体内的药代动力学。招募了 6 只健康灰狗（3 只雄性，3 只雌性）。通过液相色谱/质谱法在预定时间采集血液，以测量加巴喷丁的血浆浓度。使用计算机软件确定药代动力学参数。实际给予的平均（和范围）剂量为 10.2（9.1-12.0）mg/kg 和 20.5（18.2-24）mg/kg，分别为 10mg/kg 和 20mg/kg 目标剂量组。10mg/kg 和 20mg/kg 组的 C(MAX)均值分别为 1.3 和 1.5 小时时的 8.54 和 13.22μg/mL，终末半衰期分别为 3.3 和 3.4 小时。与 20mg/kg 组相比，10mg/kg 组的相对生物利用度为 1.13。加巴喷丁在犬体内吸收和消除迅速，表明需要频繁给药以维持最小的目标血浆浓度。
