Kirby-Madden Taylor, Waring Caitlin T, Herron Meghan
Massachusetts Veterinary Behavior, Dennis Port, MA 02639, USA.
Gigi's, Columbus, OH 43110, USA.
Animals (Basel). 2024 May 14;14(10):1462. doi: 10.3390/ani14101462.
The use of gabapentin in treating dogs with behavioral disorders is not well described. To characterize behavioral effects of gabapentin, this study surveyed 50 owners whose dogs were prescribed gabapentin at a veterinary behavior-focused practice over a five-year period. Most owners (72%) reported that gabapentin was moderately or very effective at improving their dog's behavior. The majority of owners reported at least one side effect (70%), with sedation being the most common. Sedation was more likely to be seen at doses higher than 30 mg/kg. Specific dose ranges (mg/kg) did not correlate with any other reports of side effects nor effectiveness. Dogs with a diagnosis of conflict-related aggression were more likely to have owners report that gabapentin was effective at improving behavior compared to dogs with other behavioral diagnoses ( = 0.04), while dogs diagnosed with aggression secondary to high arousal were less likely to have owners report that gabapentin was effective ( = 0.01). Overall, reports of effect varied widely and, with the exception of sedation, did not correlate with specific mg/kg dose ranges. Results suggest that some dogs may be more sensitive or resistant to adverse and/or therapeutic effects than others and multiple dosage trials may be needed before finding the best fit.
加巴喷丁用于治疗行为障碍犬的相关情况描述并不充分。为了明确加巴喷丁的行为学效应，本研究调查了50位主人，他们的犬在一家专注于兽医行为学的诊所接受了为期五年的加巴喷丁治疗。大多数主人（72%）报告称加巴喷丁在改善其犬的行为方面有中度或非常显著的效果。大多数主人报告至少出现了一种副作用（70%），其中镇静是最常见的。在高于30mg/kg的剂量下更易出现镇静作用。特定的剂量范围（mg/kg）与其他任何副作用报告或疗效均无关联。与患有其他行为诊断的犬相比，被诊断为与冲突相关攻击行为的犬的主人更有可能报告加巴喷丁在改善行为方面有效（P = 0.04），而被诊断为因高度兴奋继发攻击行为的犬的主人报告加巴喷丁有效的可能性较小（P = 0.01）。总体而言，疗效报告差异很大，除了镇静作用外，与特定的mg/kg剂量范围无关。结果表明，一些犬可能比其他犬对不良反应和/或治疗效果更敏感或更具耐受性，可能需要进行多次剂量试验才能找到最适合的方案。
