Parekh W A, Ashley D, Chubb B, Gillies H, Evans M
Novo Nordisk Limited, Gatwick, UK.
Abacus International, Bicester, UK.
Diabet Med. 2015 Sep;32(9):1156-66. doi: 10.1111/dme.12771. Epub 2015 Apr 22.
To provide estimates of the costs of severe and non-severe insulin-related hypoglycaemia in the UK using the Local Impact of Hypoglycaemia Tool.
Rates of hypoglycaemia were extracted from the UK Hypoglycaemia Study Group observational study. The costs of severe and non-severe hypoglycaemic episodes in insulin-treated adults with Type 1 and Type 2 diabetes were estimated from UK data sources. The rates and costs were then applied to specific populations to give an estimate of the cost of insulin-related hypoglycaemia for the UK, a specific locality, or a user-defined population. User-specific rates and costs could also be applied.
The estimated cost of a hypoglycaemic episode can range from as much as £2,152 for severe episodes (for which the patient is admitted to hospital) to as little as £1.67 for non-severe episodes. With a UK population of 64.1 million, the total estimated cost of managing insulin-related hypoglycaemia is £468.0 m per year (£295.9 m for severe episodes, £172.1 m for non-severe episodes). On a local health economy level, using a hypothetical general population of 100 000, the total cost of managing insulin-related hypoglycaemia is estimated to be £730,052 per year (£461,658 for severe and £268,394 for non-severe episodes).
The Local Impact of Hypoglycaemia Tool highlights the economic burden of insulin-related hypoglycaemia. Non-severe episodes are often overlooked because of their low individual cost, but their high frequency makes the cumulative cost substantial. The Local Impact of Hypoglycaemia Tool also shows clinicians and budget-holders the economic impact of lower rates of hypoglycaemia.
使用低血糖局部影响工具估算英国严重和非严重胰岛素相关低血糖的成本。
从英国低血糖研究组的观察性研究中提取低血糖发生率。根据英国数据源估算1型和2型糖尿病胰岛素治疗成人严重和非严重低血糖发作的成本。然后将发生率和成本应用于特定人群,以估算英国、特定地区或用户定义人群的胰岛素相关低血糖成本。也可应用用户特定的发生率和成本。
低血糖发作的估计成本范围从严重发作(患者住院)的高达2152英镑到非严重发作的低至1.67英镑。英国人口为6410万,管理胰岛素相关低血糖的总估计成本为每年4.68亿英镑(严重发作2.959亿英镑,非严重发作1.721亿英镑)。在当地卫生经济层面,假设普通人群为10万,管理胰岛素相关低血糖的总成本估计为每年730,052英镑(严重发作461,658英镑,非严重发作268,394英镑)。
低血糖局部影响工具凸显了胰岛素相关低血糖的经济负担。非严重发作因其个体成本低而常常被忽视,但其高频率使得累积成本相当可观。低血糖局部影响工具还向临床医生和预算管理者展示了较低低血糖发生率的经济影响。