免疫脾细胞培养上清液中的T细胞因子对小鼠速发型超敏反应样足垫反应的抗原特异性增强作用。
Antigen-specific augmentation of murine immediate hypersensitivity-like footpad reaction by a T-cell factor in the culture supernatant of immune spleen cells.
作者信息
Yamada A, Himeno K, Kumazawa Y, Nomoto K
出版信息
Cell Immunol. 1985 May;92(2):350-8. doi: 10.1016/0008-8749(85)90016-4.
An antigen-specific factor capable of augmenting delayed-type hypersensitivity (DH) in the culture supernatants from immune spleen cells and erythrocyte antigen has been found. These culture supernatants also augmented an immediate hypersensitivity-like reaction which appeared in advance of the classical DH reaction. In this paper, the basic characteristics and cells producing the augmentation factor (IAF) involved in immediate hypersensitivity-like reaction were investigated. Maximum activity of IAF was detected in a supernatant from 24-hr culture of immune spleen cells and antigen. In vitro antigen stimulation was essentially required for the production or release of IAF. IAF showed antigen-specificity. IAF was produced or released by T cells. In addition to these facts, the DH-augmentation factor proved to be a T-cell product.
已发现一种能够增强免疫脾细胞和红细胞抗原培养上清液中迟发型超敏反应（DH）的抗原特异性因子。这些培养上清液还增强了一种在经典DH反应之前出现的速发型超敏样反应。在本文中，研究了参与速发型超敏样反应的增强因子（IAF）的基本特性和产生细胞。在免疫脾细胞与抗原培养24小时的上清液中检测到IAF的最大活性。IAF的产生或释放基本上需要体外抗原刺激。IAF具有抗原特异性。IAF由T细胞产生或释放。除了这些事实外，DH增强因子被证明是一种T细胞产物。
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