环磷酸腺苷对小鼠巨噬细胞中钠和钾转运系统的影响。
The effect of cyclic AMP on Na+ and K+ transport systems in mouse macrophages.
作者信息
Diez J, Braquet P, Verna R, Nazaret C, Garay R P
出版信息
Experientia. 1985 May 15;41(5):666-7. doi: 10.1007/BF02007710.
PMID:2581803
Abstract
Exogenous cyclic AMP (cAMP) inhibits the Na+, K+-cotransport system and stimulates the Na+, K+-pump and Na+, Ca2+ exchange in mouse macrophages. These effects are enhanced by inhibition of phosphodiesterase with methylisobutylxanthine (MIX). MIX alone showed little or no effect. A similar response was observed after stimulation of endogenous production of cAMP by isoproterenol.
摘要
外源性环磷酸腺苷（cAMP）可抑制小鼠巨噬细胞中的钠钾协同转运系统，并刺激钠钾泵以及钠钙交换。用甲基异丁基黄嘌呤（MIX）抑制磷酸二酯酶可增强这些效应。单独使用MIX几乎没有效果。用异丙肾上腺素刺激内源性cAMP产生后也观察到了类似的反应。
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