Garay R, Diez J, Braquet P
Biomed Biochim Acta. 1984;43(8-9):S217-21.
Prostaglandins (including PGE1, PGE2 and PGI2) showed little or no effect on Na+ and K+ transport across human red cell membranes. Conversely, they were able to: i) inhibit Na+, K+ cotransport system, ii) stimulate Na+, K+-pump and iii) stimulate Na+, Ca2+ exchange in mouse macrophages. These effects which seem to be mediated by cyclic AMP, provoke a more rapid extrusion of a cell Na+ -load. This may counterbalance the abnormal cell Na+ regulation that appears to be associated with essential hypertension.
前列腺素（包括PGE1、PGE2和PGI2）对人类红细胞膜上的钠钾转运几乎没有影响。相反，它们能够：i）抑制钠钾协同转运系统；ii）刺激钠钾泵；iii）刺激小鼠巨噬细胞中的钠钙交换。这些似乎由环磷酸腺苷介导的作用，促使细胞内钠离子负荷更快地排出。这可能会抵消与原发性高血压相关的异常细胞钠调节。
