Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Catalonia, Spain.
Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Catalonia, Spain; Department of Physiological Sciences II, School of Medicine, University of Barcelona, Barcelona, Catalonia, Spain; Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Catalonia, Spain.
Trends Biochem Sci. 2015 May;40(5):248-56. doi: 10.1016/j.tibs.2015.03.001. Epub 2015 Mar 25.
The past few years have witnessed an exciting increase in the richness and complexity of RNA-mediated regulatory circuitries, including new types of RNA-RNA interaction that underlie key steps in gene expression control in an organized and probably hierarchic system to dictate final protein output. Both small (especially miRNAs) and long coding (lc) and noncoding (nc) RNAs contain structural domains that can sense and bind other RNAs via complementary base pairing. The versatility of the interaction confers multiple roles to RNA-RNA hybrids, from control of RNA biogenesis to competition for common targets. Here, we focus on the emerging evidence around RNA networks and their impact on gene expression regulation in light of recent breakthroughs around the crosstalk between coding RNAs and ncRNAs.
过去几年见证了 RNA 介导的调控回路的丰富性和复杂性的令人兴奋的增加，包括新类型的 RNA-RNA 相互作用，这些相互作用构成了基因表达调控的关键步骤，在一个有组织且可能是层次化的系统中，以决定最终的蛋白质输出。小 RNA（尤其是 miRNAs）和长编码 (lc) 和非编码 (nc) RNA 都包含结构域，可以通过互补碱基配对感知和结合其他 RNA。这种相互作用的多功能性赋予了 RNA-RNA 杂交体多种作用，从 RNA 生物发生的控制到对共同靶标的竞争。在这里，我们根据编码 RNA 和 ncRNA 之间串扰的最新突破，重点关注 RNA 网络的新兴证据及其对基因表达调控的影响。
