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外泌体与严重急性呼吸综合征冠状病毒2感染

Exosomes and SARS-CoV-2 infection.

作者信息

Li Liuying, Yang Zixuan, Li Jia

机构信息

Department of Traditional Chinese Medicine, Zigong First People's Hospital, Zigong, China.

Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.

出版信息

Front Immunol. 2024 Nov 26;15:1467109. doi: 10.3389/fimmu.2024.1467109. eCollection 2024.

Abstract

Exosomes, which are small extracellular vesicles, are of particular interest in studies on SARS-CoV-2 infection because of their crucial role in intercellular communication. These vesicles are released by several cell types and are rich in "cargo" such as proteins, lipids, and nucleic acids, which are vital for regulating immune response and viral pathogenesis. Exosomes have been reported to be involved in viral transmission, immune escape mechanisms, and illness development in SARS-CoV-2 infection. This review examines the current research on the contribution of exosomes to the interplay between the virus and host cells, highlighting their potential as diagnostic biomarkers and therapeutic targets in combating COVID-19.

摘要

外泌体是一种小型细胞外囊泡,由于其在细胞间通讯中的关键作用,在严重急性呼吸综合征冠状病毒2(SARS-CoV-2)感染研究中备受关注。这些囊泡由多种细胞类型释放,富含蛋白质、脂质和核酸等“货物”,它们对调节免疫反应和病毒发病机制至关重要。据报道,外泌体参与了SARS-CoV-2感染中的病毒传播、免疫逃逸机制和疾病发展。本综述探讨了目前关于外泌体在病毒与宿主细胞相互作用中作用的研究,强调了它们作为诊断生物标志物和抗击2019冠状病毒病(COVID-19)治疗靶点的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a17e/11628517/415bb7858123/fimmu-15-1467109-g001.jpg

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