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门诊环境下即时检测设备评估的血脂谱及血脂异常相关因素:中国南方的一项大规模横断面研究

Blood lipid profiles and factors associated with dyslipidemia assessed by a point-of-care testing device in an outpatient setting: A large-scale cross-sectional study in Southern China.

作者信息

Zhang Pei-dong, He Lin-yun, Guo Yang, Liu Peng, Li Gong-xin, Wang Li-zi, Liu Ying-feng

机构信息

Department of Cardiovascular Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, China; Second Clinical Medical College, Southern Medical University, Guangzhou, China.

Second Clinical Medical College, Southern Medical University, Guangzhou, China.

出版信息

Clin Biochem. 2015 Jun;48(9):586-9. doi: 10.1016/j.clinbiochem.2015.03.008. Epub 2015 Mar 25.

DOI:10.1016/j.clinbiochem.2015.03.008
PMID:25818474
Abstract

OBJECTIVE

To promote the concept of POCT and to investigate dyslipidemia in Guangzhou, China, we performed a study examining blood lipids assessed by POCT and reported factors associated with dyslipidemia.

DESIGN AND METHODS

This multicenter, cross-sectional study enrolled outpatients from 9 Guangzhou hospitals from May through September 2013. After informed consent was obtained, the following information was collected: age; gender; the presence of diabetes mellitus, obesity, and hypertension as well as current use of cigarettes or alcohol. Patients were asked to fast for 8h before the blood examination performed on a POCT device, the CardioChek PA.

RESULTS

Of 4012 patients enrolled (1544 males, 2468 females; mean age 60.35±9.41 years), 1993 (49.7%) patients had dyslipidemia, but only 101 (5.1%) took statins. The multivariate tests of associations between demographic variables, comorbidities, and the risk of having dyslipidemia found that the significant predictors of dyslipidemia were male gender, age ≥60 years, being a current smoker or alcohol drinker, and hypertension.

CONCLUSION

Most dyslipidemia patients in Guangzhou remain untreated. POCT in China is feasible, and its widespread use might improve dyslipidemia awareness, treatment and control.

摘要

目的

为推广即时检验(POCT)的理念并调查中国广州的血脂异常情况,我们开展了一项研究,检测通过POCT评估的血脂水平,并报告与血脂异常相关的因素。

设计与方法

这项多中心横断面研究纳入了2013年5月至9月期间来自广州9家医院的门诊患者。在获得知情同意后,收集了以下信息:年龄;性别;糖尿病、肥胖症和高血压的患病情况以及当前吸烟或饮酒情况。要求患者在使用POCT设备CardioChek PA进行血液检查前禁食8小时。

结果

在纳入的4012例患者中(男性1544例,女性2468例;平均年龄60.35±9.41岁),1993例(49.7%)患者患有血脂异常,但只有101例(5.1%)服用他汀类药物。对人口统计学变量、合并症与血脂异常风险之间的关联进行多变量检验发现,血脂异常的显著预测因素为男性、年龄≥60岁、当前吸烟或饮酒以及高血压。

结论

广州大多数血脂异常患者仍未接受治疗。POCT在中国是可行的,其广泛应用可能会提高对血脂异常的认识、治疗和控制水平。

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