Elewa Rana M, Abdallah Marwa A, Zouboulis Christos C
Departments of Dermatology, Venereology, Allergology and Immunology, Dessau Medical Center, Dessau, Germany; Departments of Dermatology, Venereology and Andrology, Ain Shams University, Faculty of Medicine, Cairo, Egypt.
J Dermatol. 2015 May;42(5):467-76. doi: 10.1111/1346-8138.12793. Epub 2015 Mar 26.
Skin aging is the most apparent form of senescence and could reflect the aging of inner organs. Molecular changes involved in innate immunity signaling, tumorigenesis, and inflammation were studied. Protein levels were evaluated based on the immunohistochemistry of the skin of 42 young and old individuals. The investigated molecules (peroxisome proliferator-activated receptors-α and -γ, Toll-like receptor 4, and interleukin-6 and 8) were expressed in almost all skin compartments and exhibited significant aging-associated downregulation in epithelial tissues, mostly in the sebaceous glands, the sweat glands, and the epidermis. With the exception of interleukin-6 in the dermal tissue, no upregulation was detected in the aged group. The results obtained indicate an interesting interaction between different pathways of aging, namely defective stress responses, downregulated innate immunity responses, and activation of the tumorigenesis pathway, which was especially apparent in the sebaceous glands.
皮肤衰老是衰老最明显的形式，且能反映内部器官的老化。对涉及先天免疫信号传导、肿瘤发生和炎症的分子变化进行了研究。基于42名年轻和老年个体皮肤的免疫组织化学评估蛋白质水平。所研究的分子（过氧化物酶体增殖物激活受体-α和-γ、Toll样受体4以及白细胞介素-6和8）几乎在所有皮肤区域均有表达，且在上皮组织中呈现出与衰老相关的显著下调，主要是在皮脂腺、汗腺和表皮。除真皮组织中的白细胞介素-6外，老年组未检测到上调。所得结果表明不同衰老途径之间存在有趣的相互作用，即应激反应缺陷、先天免疫反应下调以及肿瘤发生途径激活，这在皮脂腺中尤为明显。
