Desiderio J V, Campbell S G
Infect Immun. 1985 Jun;48(3):658-63. doi: 10.1128/iai.48.3.658-663.1985.
Partially delipidated Salmonella typhimurium (O-1,4,5,12) lipopolysaccharide was incorporated into small multilamellar liposomes composed of either naturally occurring or synthetic phospholipids. Vaccination of mice with the liposome-lipopolysaccharide complexes induced a cellular response specific for O-1,4,5,12 determinants, as determined by the development of a delayed-type hypersensitivity reaction. The liposome-lipopolysaccharide vaccines were significantly more effective, compared with other nonviable vaccines tested, in protecting mice against a lethal intravenous challenge infection with virulent S. typhimurium. Protection afforded by the liposome-lipopolysaccharide vaccines was comparable to that conferred by a live S. typhimurium vaccine. Results suggest that liposome-induced modulation of the host immune response in favor of cell-mediated immunity may be more efficacious in preventing diseases in which cell-mediated immunity is of prime importance.
将部分脱脂的鼠伤寒沙门氏菌（O-1,4,5,12）脂多糖掺入由天然存在的或合成的磷脂组成的小多层脂质体中。用脂质体-脂多糖复合物对小鼠进行疫苗接种可诱导针对O-1,4,5,12决定簇的细胞反应，这通过迟发型超敏反应的发展来确定。与测试的其他非活性疫苗相比，脂质体-脂多糖疫苗在保护小鼠免受强毒鼠伤寒沙门氏菌致死性静脉内攻击感染方面明显更有效。脂质体-脂多糖疫苗提供的保护与活鼠伤寒沙门氏菌疫苗提供的保护相当。结果表明，脂质体诱导的宿主免疫反应调节有利于细胞介导的免疫，在预防细胞介导的免疫至关重要的疾病中可能更有效。
