Immunity to Salmonella infection.

The foregoing literature review and data presentation have been set forth in the hope of clarifying some complex and confusing issues in regard to Salmonella infection. From a practical point of view, the information presented has implications for the direction to take with regard to improving the current typhoid vaccine, as the presently used acetone-killed cell preparation has considerable toxicity. The issues are important from a theoretical standpoint, because they have bearing on the nature of the concepts researchers and clinicians carry as working hypothesis with regard to the mechanisms of immunity to Salmonella infection. An incomplete appreciation of the literature seems to have led many scientists to believe that only cellular immunity can protect a mouse, and by analogy a human, against Salmonella. The logical deduction from such a premise is that only live vaccines will be effective in humans againsT S. typhi. Such a conclusion would appear unfounded, as documented in this review, for killed vaccines have been shown to be highly effective in vaccinating many mouse strains, as well as humans, against enteric fever.