Huang Sheng, Kou Binquan, Chi Yayun, Xi Yan, Cao Yixin, Cui Wenli, Hu Xin, Shao Zhimin, Guo Han, Fu Yanan, Xiao Tiqiao, Sun Jianqi, Zhao Jun, Wang Yujie, Wu Jiong
Department of Breast Surgery, Breast Cancer Institute, Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People's Republic of China.
Department of Physics and Astronomy, Shanghai Jiao Tong University, Shanghai, People's Republic of China.
Sci Rep. 2015 Mar 30;5:9418. doi: 10.1038/srep09418.
Current bio-medical imaging researches aim to detect brain micrometastasis in early stage for its increasing incidence and high mortality rates. Synchrotron phase-contrast imaging techniques, such as in-line phase-contrast (IPC) and grating-based phase-contrast (GPC) imaging, could provide a high spatial and density imaging study of biological specimens' 3D structures. In this study, we demonstrated the detection efficiencies of these two imaging tools on breast cancer micrometastasis in an ex vivo mouse brain. We found that both IPC and GPC can differentiate abnormal brain structures induced by micrometastasis from the surrounding normal tissues. We also found that GPC was more sensitive in detecting the small metastasis as compared to IPC.
当前生物医学成像研究旨在早期检测脑微转移，因为其发病率不断上升且死亡率很高。同步辐射相衬成像技术，如同轴相衬（IPC）和基于光栅的相衬（GPC）成像，可以对生物标本的三维结构进行高空间分辨率和密度的成像研究。在本研究中，我们展示了这两种成像工具在体外小鼠脑内对乳腺癌微转移的检测效率。我们发现IPC和GPC都能将微转移诱导的异常脑结构与周围正常组织区分开来。我们还发现，与IPC相比，GPC在检测小转移灶方面更敏感。
