• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

小鼠肝脏门静脉用放射性透性栓塞剂栓塞的在线相衬成像：一项初步研究。

In-line phase contrast imaging of hepatic portal vein embolization with radiolucent embolic agents in mice: a preliminary study.

作者信息

Tang Rongbiao, Huang Wei, Yan Fuhua, Lu Yong, Chai Wei-Min, Yang Guo-Yuan, Chen Ke-Min

机构信息

Department of Radiology, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.

出版信息

PLoS One. 2013 Dec 4;8(12):e80919. doi: 10.1371/journal.pone.0080919. eCollection 2013.

DOI:10.1371/journal.pone.0080919
PMID:24324646
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3851775/
Abstract

It is crucial to understand the distribution of embolic agents inside target liver during and after the hepatic portal vein embolization (PVE) procedure. For a long time, the problem has not been well solved due to the radiolucency of embolic agents and the resolution limitation of conventional radiography. In this study, we first reported use of fluorescent carboxyl microspheres (FCM) as radiolucent embolic agents for embolizing hepatic portal veins. The fluorescent characteristic of FCM could help to determine their approximate location easily. Additionally, the microspheres were found to be fairly good embolizing agents for PVE. After the livers were excised and fixed, they were imaged by in-line phase contrast imaging (PCI), which greatly improved the detection of the radiolucent embolic agents as compared to absorption contrast imaging (ACI). The preliminary study has for the first time shown that PCI has great potential in the pre-clinical investigation of PVE with radiolucent embolic agents.

摘要

了解肝门静脉栓塞（PVE）过程中及术后栓塞剂在目标肝脏内的分布情况至关重要。长期以来，由于栓塞剂的射线可透性以及传统放射成像的分辨率限制，该问题一直未得到很好的解决。在本研究中，我们首次报道了使用荧光羧基微球（FCM）作为射线可透性栓塞剂来栓塞肝门静脉。FCM的荧光特性有助于轻松确定其大致位置。此外，发现这些微球是用于PVE的相当好的栓塞剂。在肝脏被切除并固定后，通过在线相衬成像（PCI）对其进行成像，与吸收对比成像（ACI）相比，这极大地提高了对射线可透性栓塞剂的检测。这项初步研究首次表明，PCI在使用射线可透性栓塞剂进行PVE的临床前研究中具有巨大潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4e6/3851775/5d00428a7a07/pone.0080919.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4e6/3851775/49c510e96e1f/pone.0080919.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4e6/3851775/016038efd95c/pone.0080919.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4e6/3851775/7ac3176b705f/pone.0080919.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4e6/3851775/9c45cb3c1d40/pone.0080919.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4e6/3851775/45ba2077f825/pone.0080919.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4e6/3851775/5d00428a7a07/pone.0080919.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4e6/3851775/49c510e96e1f/pone.0080919.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4e6/3851775/016038efd95c/pone.0080919.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4e6/3851775/7ac3176b705f/pone.0080919.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4e6/3851775/9c45cb3c1d40/pone.0080919.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4e6/3851775/45ba2077f825/pone.0080919.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4e6/3851775/5d00428a7a07/pone.0080919.g006.jpg

相似文献

1
In-line phase contrast imaging of hepatic portal vein embolization with radiolucent embolic agents in mice: a preliminary study.小鼠肝脏门静脉用放射性透性栓塞剂栓塞的在线相衬成像：一项初步研究。
PLoS One. 2013 Dec 4;8(12):e80919. doi: 10.1371/journal.pone.0080919. eCollection 2013.
2
Analysis of the efficacy of portal vein embolization for patients with extensive liver malignancy and very low future liver remnant volume, including a comparison with the associating liver partition with portal vein ligation for staged hepatectomy approach.广泛肝脏恶性肿瘤且未来残余肝脏体积非常低的患者行门静脉栓塞术的疗效分析，包括与联合肝脏离断和门静脉结扎的分期肝切除术的比较。
J Am Coll Surg. 2013 Jul;217(1):126-33; discussion 133-4. doi: 10.1016/j.jamcollsurg.2013.03.004. Epub 2013 Apr 28.
3
Portal vein embolization: rationale, outcomes, controversies and future directions.门静脉栓塞术：原理、结果、争议和未来方向。
Expert Rev Gastroenterol Hepatol. 2010 Aug;4(4):489-501. doi: 10.1586/egh.10.41.
4
Hepatic vein embolization after portal vein embolization to induce additional liver hypertrophy in patients with metastatic colorectal carcinoma.经门静脉栓塞后行肝静脉栓塞以诱导转移性结直肠癌患者肝脏额外肥大。
Eur Radiol. 2020 Jul;30(7):3862-3868. doi: 10.1007/s00330-020-06746-4. Epub 2020 Mar 7.
5
Evaluating surgeon attitudes towards the safety and efficacy of portal vein occlusion and associating liver partition and portal vein ligation: a report of the MALINSA survey.评估外科医生对门静脉闭塞及联合肝脏分隔和门静脉结扎术的安全性和有效性的态度：MALINSA调查结果报告
HPB (Oxford). 2015 Oct;17(10):936-41. doi: 10.1111/hpb.12439. Epub 2015 Aug 10.
6
Future liver remnant growth after various portal vein embolization regimens: a quantitative comparison.不同门静脉栓塞方案后未来肝残余体积的增长：定量比较
Minim Invasive Ther Allied Technol. 2020 Apr;29(2):98-106. doi: 10.1080/13645706.2019.1582067. Epub 2019 Mar 1.
7
Preoperative portal vein embolization with a combination of trisacryl microspheres, gelfoam and coils.术前采用三丙烯酸微球、明胶海绵和弹簧圈联合进行门静脉栓塞。
Diagn Interv Imaging. 2015 Jan;96(1):57-64. doi: 10.1016/j.diii.2013.07.004. Epub 2013 Sep 3.
8
[ROENTGEN-ENDOVASCULAR EMBOLIZATION OF THE PORTAL VEIN BRANCHES AS A PATIENTS CONDITIONING FOR EXTENSIVE HEPATIC RESECTION].[门静脉分支的X线血管内栓塞术作为广泛肝切除术患者的预处理]
Klin Khir. 2015 Apr(4):5-8.
9
Liver regeneration following repeated reversible portal vein embolization in an experimental model.实验模型中重复可逆门静脉栓塞后肝脏再生。
Br J Surg. 2016 Aug;103(9):1209-19. doi: 10.1002/bjs.10153. Epub 2016 Jun 3.
10
Preoperative Portal Vein Embolization before Major Hepatectomy in Patients with Excess Bilirubin does not Affect Hypertrophy of Remnant Liver and Postoperative Outcomes.胆红素过高患者在进行大型肝切除术前进行门静脉栓塞术不会影响残余肝脏的肥大及术后结果。
Hepatogastroenterology. 2014 Jun;61(132):908-15.

引用本文的文献

1
Visualization of the hatching of brine shrimp eggs using ultrafast and high-resolution phase-contrast CTs.使用超快和高分辨率相衬CT对卤虫虫卵孵化进行可视化。
APL Bioeng. 2025 Mar 7;9(1):016113. doi: 10.1063/5.0238482. eCollection 2025 Mar.
2
Phase Contrast Imaging Based Microbubble Monitoring of Radiofrequency Ablation: An Study.基于相衬成像的射频消融术中微泡监测：一项研究
Front Oncol. 2020 Aug 25;10:1709. doi: 10.3389/fonc.2020.01709. eCollection 2020.
3
Molecular evaluation of thrombosis using X-ray phase contrast imaging with microbubbles targeted to P-selectin in mice.

本文引用的文献

1
CO₂-based in-line phase contrast imaging of small intestine in mice.基于二氧化碳的小鼠小肠在线相衬成像。
Sci Rep. 2013;3:2313. doi: 10.1038/srep02313.
2
Quantifying morphological parameters of the terminal branching units in a mouse lung by phase contrast synchrotron radiation computed tomography.利用相衬同步辐射计算机断层扫描技术定量分析小鼠肺部终末分支单元的形态参数。
PLoS One. 2013 May 21;8(5):e63552. doi: 10.1371/journal.pone.0063552. Print 2013.
3
Phase contrast imaging reveals low lung volumes and surface areas in the developing marsupial.
利用靶向P-选择素的微泡通过X射线相衬成像对小鼠血栓形成进行分子评估。
Eur Radiol. 2016 Sep;26(9):3253-61. doi: 10.1007/s00330-015-4129-x. Epub 2015 Dec 2.
4
In-line phase-contrast and grating-based phase-contrast synchrotron imaging study of brain micrometastasis of breast cancer.乳腺癌脑微转移的在线相衬和基于光栅的相衬同步辐射成像研究
Sci Rep. 2015 Mar 30;5:9418. doi: 10.1038/srep09418.
相差成像显示发育中的有袋目动物的低肺容量和表面积。
PLoS One. 2013;8(1):e53805. doi: 10.1371/journal.pone.0053805. Epub 2013 Jan 18.
4
X-ray phase-contrast imaging: from pre-clinical applications towards clinics.X 射线相衬成像：从临床前应用走向临床。
Phys Med Biol. 2013 Jan 7;58(1):R1-35. doi: 10.1088/0031-9155/58/1/R1. Epub 2012 Dec 10.
5
X-ray phase contrast imaging of cell isolation with super-paramagnetic microbeads.基于超顺磁微珠的细胞分离的 X 射线相位衬度成像。
PLoS One. 2012;7(9):e45597. doi: 10.1371/journal.pone.0045597. Epub 2012 Sep 24.
6
Visualising liver fibrosis by phase-contrast X-ray imaging in common bile duct ligated mice.通过在胆总管结扎小鼠中进行相位对比 X 射线成像来可视化肝纤维化。
Eur Radiol. 2013 Feb;23(2):417-23. doi: 10.1007/s00330-012-2630-z. Epub 2012 Aug 19.
7
PITRE: software for phase-sensitive X-ray image processing and tomography reconstruction.皮特雷：用于相敏 X 射线图像处理和断层重建的软件。
J Synchrotron Radiat. 2012 Sep;19(Pt 5):836-45. doi: 10.1107/S0909049512029731. Epub 2012 Aug 2.
8
Current status of embolic agents for liver tumor embolization.肝肿瘤栓塞用栓塞剂的现状。
Int J Clin Oncol. 2012 Aug;17(4):306-15. doi: 10.1007/s10147-012-0445-1. Epub 2012 Jul 18.
9
Using X-ray in-line phase-contrast imaging for the investigation of nude mouse hepatic tumors.应用 X 射线相衬成像技术研究裸鼠肝肿瘤。
PLoS One. 2012;7(6):e39936. doi: 10.1371/journal.pone.0039936. Epub 2012 Jun 28.
10
Anti-VEGFR2-conjugated PLGA microspheres as an x-ray phase contrast agent for assessing the VEGFR2 expression.抗 VEGFR2 修饰的 PLGA 微球作为 X 射线相衬造影剂用于评估 VEGFR2 表达。
Phys Med Biol. 2012 May 21;57(10):3051-63. doi: 10.1088/0031-9155/57/10/3051. Epub 2012 Apr 26.