Augustin Iris
Division Signaling and Functional Genomics, German Cancer Research Center (DKFZ), Department of Cell and Molecular Biology, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany.
J Dtsch Dermatol Ges. 2015 Apr;13(4):302-6. doi: 10.1111/ddg.12620.
The mammalian skin mediates the primary interphase between the body and the external environment and provides the first line of defense against pathogens, mechanical trauma, sunlight injuries, and chemical stress. Proper physical, biochemical, and immunological composition of the skin is necessary to maintain its barrier function. Therefore, the skin reflects a complex dynamic organ with high cellular turnover during normal tissue replacement and wound repair. Stem cell reservoirs ensure constant skin renewal. Wnt signaling controls stem cell maintenance and fate decisions in various tissues and also reflects a key pathway in controlling skin development and homeostasis. Disruption of Wnt signaling in the skin causes disorders such as alopecia, chronic inflammatory skin diseases or cancer. This review summarizes the role of Wnt signaling during skin development, homeostasis, and disease.
哺乳动物的皮肤介导了机体与外部环境之间的主要界面，并提供了抵御病原体、机械创伤、阳光损伤和化学应激的第一道防线。皮肤具备适当的物理、生化和免疫组成对于维持其屏障功能至关重要。因此，皮肤是一个复杂的动态器官，在正常组织更替和伤口修复过程中细胞更新率很高。干细胞库确保皮肤持续更新。Wnt信号通路控制着各种组织中的干细胞维持和命运决定，也是控制皮肤发育和稳态的关键途径。皮肤中Wnt信号通路的破坏会导致脱发、慢性炎症性皮肤病或癌症等疾病。本综述总结了Wnt信号通路在皮肤发育、稳态和疾病中的作用。
