Houschyar K S, Tapking C, Puladi B, Popp D, Duscher D, Rein S, Reumuth G, Grieb G, Branski L K, Siemers F, Lehnhardt M, Yazdi A S
Klinik für Dermatologie und Allergologie - Hautklinik, Universitätsklinik der RWTH Aachen.
Klinik für Hand-, Plastische- und Rekonstruktive Chirurgie, Schwerbrandverletztenzentrum, BG Unfallklinik Ludwigshafen, Universität Heidelberg.
Handchir Mikrochir Plast Chir. 2020 Apr;52(2):151-158. doi: 10.1055/a-1017-3600. Epub 2019 Nov 13.
Human skin is an efficient barrier that protects the organism from noxious substances. Wounds destroy this barrier. Wound healing is a phased physiological regeneration of the destroyed tissue that ideally leads to occlusion of a wound, in particular by regeneration of connective tissue and capillaries. The Wnt signaling pathway is a highly conserved signal transduction cascade across the animal kingdom that controls basic cellular interactions in multicellular organisms. Accordingly, through the Wnt signaling path many processes, e. g. as the balance between proliferation and differentiation or apoptosis, coordinated. Wnt signaling is activated by a wound and participates in each subsequent phase of the healing process, beginning with inflammatory control and programmed cell death, to the mobilization of stem cells within the wound. Endogenous Wnt signaling is an attractive therapeutic approach to assist in the repair of skin wounds, as the complex mechanisms of the Wnt signaling pathway have become increasingly understood over the years. This review summarizes current data to clarify the role of Wnt signaling in the wound healing process of the skin.
人类皮肤是一种有效的屏障，可保护机体免受有害物质侵害。伤口会破坏这一屏障。伤口愈合是受损组织的阶段性生理再生过程，理想情况下会导致伤口闭合，特别是通过结缔组织和毛细血管的再生实现。Wnt信号通路是动物界高度保守的信号转导级联反应，控制多细胞生物中的基本细胞相互作用。因此，通过Wnt信号通路，许多过程，例如增殖与分化或细胞凋亡之间的平衡得以协调。伤口会激活Wnt信号，且该信号参与愈合过程的每个后续阶段，从炎症控制和程序性细胞死亡开始，到伤口内干细胞的动员。内源性Wnt信号是协助修复皮肤伤口的一种有吸引力的治疗方法，因为这些年来人们对Wnt信号通路的复杂机制已有越来越深入的了解。本综述总结了当前数据，以阐明Wnt信号在皮肤伤口愈合过程中的作用。
