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哺乳动物表皮中的稳态、再生与肿瘤形成

Homeostasis, regeneration and tumour formation in the mammalian epidermis.

作者信息

Belokhvostova Daria, Berzanskyte Ieva, Cujba Ana-Maria, Jowett Geraldine, Marshall Lucy, Prueller Johanna, Watt Fiona M

机构信息

King's College London Centre for Stem Cells and Regenerative Medicine, Guy's Hospital, London, UK.

出版信息

Int J Dev Biol. 2018;62(6-7-8):571-582. doi: 10.1387/ijdb.170341fw.

DOI:10.1387/ijdb.170341fw
PMID:29938768
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6103439/
Abstract

The epidermis is the outer covering of the skin and provides a protective interface between the body and the environment. It is well established that the epidermis is maintained by stem cells that self-renew and generate differentiated cells. In this review, we discuss how recent technological advances, including single cell transcriptomics and in vivo imaging, have provided new insights into the nature and plasticity of the stem cell compartment and the differing roles of stem cells in homeostasis, wound repair and cancer.

摘要

表皮是皮肤的外层覆盖物，在身体与环境之间提供一个保护性界面。众所周知，表皮由自我更新并产生分化细胞的干细胞维持。在本综述中，我们讨论了包括单细胞转录组学和体内成像在内的最新技术进展如何为干细胞区室的性质和可塑性以及干细胞在稳态、伤口修复和癌症中的不同作用提供了新的见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8159/6103439/8a9053803e19/emss-78459-f005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8159/6103439/b6bb9bca0cbb/emss-78459-f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8159/6103439/fda293171270/emss-78459-f002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8159/6103439/30d00a49c8d4/emss-78459-f003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8159/6103439/a8c8a37242dd/emss-78459-f004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8159/6103439/8a9053803e19/emss-78459-f005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8159/6103439/b6bb9bca0cbb/emss-78459-f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8159/6103439/fda293171270/emss-78459-f002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8159/6103439/30d00a49c8d4/emss-78459-f003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8159/6103439/a8c8a37242dd/emss-78459-f004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8159/6103439/8a9053803e19/emss-78459-f005.jpg

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Correction of aberrant growth preserves tissue homeostasis.纠正异常生长可维持组织内稳态。
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Regulatory T Cells in Skin Facilitate Epithelial Stem Cell Differentiation.皮肤中的调节性T细胞促进上皮干细胞分化。
伤口位置和 housing 条件决定修复动态和瘢痕形成。 注：这里“housing conditions”不太明确准确含义，可能是“饲养条件”之类的，结合上下文可能更精准，但仅从字面翻译就是这样。
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YAP/TAZ Signalling Controls Epidermal Keratinocyte Fate.YAP/TAZ信号传导控制表皮角质形成细胞的命运。
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GPCR Screening Reveals that the Metabolite Receptor HCAR3 Regulates Epithelial Proliferation, Migration, and Cellular Respiration.GPCR 筛选揭示代谢物受体 HCAR3 调节上皮细胞增殖、迁移和细胞呼吸。
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Research Progress of mA RNA Methylation in Skin Diseases.mRNA 甲基化在皮肤病中的研究进展。
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