哺乳动物表皮中的稳态、再生与肿瘤形成
Homeostasis, regeneration and tumour formation in the mammalian epidermis.
作者信息
Belokhvostova Daria, Berzanskyte Ieva, Cujba Ana-Maria, Jowett Geraldine, Marshall Lucy, Prueller Johanna, Watt Fiona M
机构信息
King's College London Centre for Stem Cells and Regenerative Medicine, Guy's Hospital, London, UK.
出版信息
Int J Dev Biol. 2018;62(6-7-8):571-582. doi: 10.1387/ijdb.170341fw.
Abstract
The epidermis is the outer covering of the skin and provides a protective interface between the body and the environment. It is well established that the epidermis is maintained by stem cells that self-renew and generate differentiated cells. In this review, we discuss how recent technological advances, including single cell transcriptomics and in vivo imaging, have provided new insights into the nature and plasticity of the stem cell compartment and the differing roles of stem cells in homeostasis, wound repair and cancer.
摘要
表皮是皮肤的外层覆盖物，在身体与环境之间提供一个保护性界面。众所周知，表皮由自我更新并产生分化细胞的干细胞维持。在本综述中，我们讨论了包括单细胞转录组学和体内成像在内的最新技术进展如何为干细胞区室的性质和可塑性以及干细胞在稳态、伤口修复和癌症中的不同作用提供了新的见解。
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