Araujo-Pires Ana Claudia, Mendes Vanessa Cristina, Ferreira-Junior Osny, Carvalho Paulo Sérgio Perri, Guan Limin, Davies John Edward
School of Dentistry, Stomatology and Oral Surgery Bauru, University of São Paulo, Bauru, São Paulo, Brazil.
Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON, Canada.
Clin Implant Dent Relat Res. 2016 Jun;18(3):559-70. doi: 10.1111/cid.12326. Epub 2015 Mar 25.
It is expected that 40% to 60% of initial alveolar bone volume will be lost up to 6 months after tooth extraction. OsteoScaf(TM) (TRT, Toronto, ON, Canada) (poly (DL-lactide-co-glycololide/calcium phosphate [PLGA/CaP] scaffold) is a novel bone substitute material and represents a promising alternative for maintaining alveolar bone integrity in this clinical scenario.
Here it was hypothesized that OsteoScaf would reduce alveolar bone lost after tooth extraction in patient, acting as a clot-retention device.
A total of 10 patients (32 sockets) were included in the study, of which 16 sockets were grafted with OsteoScaf and 16 were used as control (coagulum alone). Cone beam computed tomography (CBCT) was performed both immediately following extraction and also at 120 days postoperatively, at which time biopsy samples were also harvested for histological analyses.
Quantitative analysis of CBCT showed less bone resorption in the OsteoScaf groups, being 10.5% to 14.4% less bone lost in the center of the socket, 15.4% in the buccal region, and 12.6% in the palatal. Qualitative histological analysis showed new bone tissue in direct apposition to the scaffold - demonstrating its osteoconductive nature.
OsteoScaf diminished the expected bone lost during the postextraction remodeling of the alveolar bone ridge at 120 days postextraction.
预计拔牙后6个月内，初始牙槽骨体积的40%至60%将会流失。OsteoScaf（TRT，多伦多，安大略省，加拿大）（聚（DL-丙交酯-共-乙交酯/磷酸钙[PLGA/CaP]支架）是一种新型骨替代材料，在这种临床情况下，是维持牙槽骨完整性的一种有前景的替代方案。
在此假设OsteoScaf作为一种血凝块保留装置，可减少患者拔牙后牙槽骨的流失。
本研究共纳入10例患者（32个牙槽窝），其中16个牙槽窝植入OsteoScaf，16个作为对照（仅血凝块）。拔牙后即刻及术后120天均进行锥形束计算机断层扫描（CBCT），此时还采集活检样本进行组织学分析。
CBCT定量分析显示，OsteoScaf组骨吸收较少，牙槽窝中心骨流失减少10.5%至14.4%，颊侧区域减少15.4%，腭侧减少12.6%。定性组织学分析显示，新骨组织直接与支架并置，证明其具有骨传导性。
OsteoScaf减少了拔牙后120天牙槽骨嵴拔牙后重塑过程中预期的骨流失。
