Department of Mechanical & Aerospace Engineering, Monash University, Victoria 3800, Australia.
Adv Drug Deliv Rev. 2015 May;85:100-9. doi: 10.1016/j.addr.2015.03.010. Epub 2015 Mar 27.
Alterations in regional lung function due to respiratory infection have a significant effect on the deposition of inhaled treatments. This has consequences for treatment effectiveness and hence recovery of lung function. In order to advance our understanding of respiratory infection and inhaled treatment delivery, we must develop imaging techniques that can provide regional functional measurements of the lung. In this review, we explore the role of functional imaging for the assessment of respiratory infection and development of inhaled treatments. We describe established and emerging functional lung imaging methods. The effect of infection on lung function is described, and the link between regional disease, function, and inhaled treatments is discussed. The potential for lung function imaging to provide unique insights into the functional consequences of infection, and its treatment, is also discussed.
由于呼吸道感染导致的区域性肺功能改变对吸入治疗的沉积有重大影响。这对治疗效果和肺功能的恢复有影响。为了提高我们对呼吸道感染和吸入治疗的认识，我们必须开发能够提供肺部区域性功能测量的成像技术。在这篇综述中，我们探讨了功能成像在评估呼吸道感染和开发吸入治疗中的作用。我们描述了已建立和新兴的功能性肺部成像方法。描述了感染对肺功能的影响，并讨论了区域性疾病、功能和吸入治疗之间的联系。还讨论了肺功能成像提供对感染及其治疗的功能后果的独特见解的潜力。
