Palzer Andreas, Eddicks Matthias, Zoels Susanne, Stark Jasmin, Reese Sven, Strutzberg-Minder Katrin, Fiebig Kerstin, Ritzmann Mathias
Clinic for Swine, Ludwig-Maximilians-University Munich, Sonnenstrasse 16, D-85764 Oberschleissheim, Germany.
Clinic for Swine, Ludwig-Maximilians-University Munich, Sonnenstrasse 16, D-85764 Oberschleissheim, Germany.
Prev Vet Med. 2015 May 1;119(3-4):134-40. doi: 10.1016/j.prevetmed.2015.03.005. Epub 2015 Mar 17.
The aim of the study was to compare the efficacy and compatibility of a separate or combined vaccination against the porcine reproductive and respiratory syndrome (PRRS) and Haemophilus (H.) parasuis. The study was conducted in a 1200 head nursery farm. A total of 360 piglets at an age of 26 days were randomized into three groups. Group A was vaccinated separately against H. parasuis (Porcilis(®)Glässer) and PRRS (Porcilis(®)PRRS), group B was vaccinated with a combined vaccine of both vaccines and group C remained unvaccinated as control group. The compatibility was evaluated by measurement of the body temperature and a palpation score of the injection site 0, 4, 24 and 72 h after vaccination. During the nursery and the fattening period the average daily weight gain (ADWG), the number of runts and the mortality was evaluated. Additionally blood samples were taken every 2 weeks during the nursery period to perform an OppA-ELISA and a PCR for PRRS virus. No significant difference could be seen regarding the body temperature between group A and group C. Piglets which were vaccinated with the combined vaccine showed a significantly higher body temperature 4 and 72 h post vaccination than piglets from group A. The palpation score was significantly higher in group A 4 and 24h post vaccination compared to the control group, whereas no significant difference was observed between group A and B. No significant differences between groups were seen in the ADWG during the nursery period. The mortality rate during the nursery period was significantly higher in group C than in group A. The ADWG during fattening was significantly higher in the vaccinated groups than in group C. A PRRS genotype1 field virus was detected at the end of the nursery period. No significant differences were observed in the number of OppA-ELISA positive animals, but vaccinated pigs seemed to react earlier. All pigs of the vaccinated groups that were positive in the OppA-ELISA did not develop Glässer's disease and remained in the study until slaughter. The combined administration had no negative influence on efficacy but showed a slightly worse compatibility than the separate administration of both vaccines. The results of the present study indicate that vaccination against Glässer's disease using Porcilis(®)Glässer might influence the results of the OppA-ELISA.
本研究的目的是比较针对猪繁殖与呼吸综合征（PRRS）和副猪嗜血杆菌（H. parasuis）单独接种疫苗或联合接种疫苗的效果及相容性。该研究在一个有1200头仔猪的保育猪场进行。总共360头26日龄的仔猪被随机分为三组。A组分别接种副猪嗜血杆菌疫苗（Porcilis(®)Glässer）和PRRS疫苗（Porcilis(®)PRRS），B组接种两种疫苗的联合疫苗，C组不接种作为对照组。通过在接种后0、4、24和72小时测量体温及触诊注射部位评分来评估相容性。在保育期和育肥期评估平均日增重（ADWG）、弱小仔猪数量和死亡率。此外，在保育期每2周采集血样进行OppA - ELISA检测和PRRS病毒的PCR检测。A组和C组之间在体温方面未见显著差异。接种联合疫苗的仔猪在接种后4小时和72小时体温显著高于A组仔猪。与对照组相比，A组在接种后4小时和24小时的触诊评分显著更高，而A组和B组之间未见显著差异。在保育期各组之间的ADWG未见显著差异。保育期C组的死亡率显著高于A组。育肥期接种疫苗组的ADWG显著高于C组。在保育期结束时检测到一株PRRS基因型1的田间病毒。在OppA - ELISA阳性动物数量上未见显著差异，但接种疫苗的猪似乎反应更早。OppA - ELISA检测呈阳性的接种组所有猪均未发生格氏病，并一直留在研究中直至屠宰。联合接种对效果没有负面影响，但与两种疫苗单独接种相比，相容性略差。本研究结果表明使用Porcilis(®)Glässer疫苗接种预防格氏病可能会影响OppA - ELISA检测结果。
