镍催化未活化的C(sp(3))-H键与二硫化物的直接硫醇化反应。
Nickel-catalyzed direct thiolation of unactivated C(sp(3))-H bonds with disulfides.
作者信息
Yan Sheng-Yi, Liu Yue-Jin, Liu Bin, Liu Yan-Hua, Zhang Zhuo-Zhuo, Shi Bing-Feng
机构信息
Department of Chemistry, Zhejiang University, Hangzhou 310027, China.
出版信息
Chem Commun (Camb). 2015 Apr 30;51(34):7341-4. doi: 10.1039/c5cc01436k.
PMID:25820073
Abstract
The first nickel-catalyzed thiolation of unactivated C(sp(3))-H bonds with disulfides was described. This transformation uses (dppp)NiCl2 as a catalyst and BINOL as a ligand, which are efficient for the thiolation of β-methyl C(sp(3))-H bonds of a broad range of aliphatic carboxamides. The reaction provides an efficient synthetic pathway to access diverse thioethers.
摘要
首次报道了未活化的C(sp(3))-H键与二硫化物的镍催化硫醇化反应。该转化反应使用(dppp)NiCl2作为催化剂，BINOL作为配体，它们对多种脂肪族酰胺的β-甲基C(sp(3))-H键的硫醇化反应很有效。该反应为合成各种硫醚提供了一条有效的途径。
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