Saites Louis N, Goldsmith Zachary, Densky Jaron, Guedes Vivian A, Boughter John D
Department of Anatomy & Neurobiology, University of Tennessee Health Science Center, 855 Monroe Avenue, Suite 515, Memphis, TN 38163, USA
Department of Anatomy & Neurobiology, University of Tennessee Health Science Center, 855 Monroe Avenue, Suite 515, Memphis, TN 38163, USA.
Chem Senses. 2015 Jun;40(5):295-303. doi: 10.1093/chemse/bjv010. Epub 2015 Mar 28.
Previous electrophysiological investigation shows that combinations of compounds classified by humans as umami-tasting, such as glutamate salts and 5'-ribonucleotides, elicit synergistic responses in neurons throughout the rodent taste system and produce a pattern that resembles responses to sweet compounds. The current study tested the hypothesis that a synergistic mixture of monopotassium glutamate (MPG) and inositol monophosphate (IMP) possesses perceptual similarity to sucrose in mice. We estimated behavioral similarity among these tastants and the individual umami compounds using a series of conditioned taste aversion (CTA) tests, a procedure that measures whether a CTA formed to one stimulus generalizes to another. Our primary finding was that a CTA to a synergistic mixture of MPG + IMP generalizes to sucrose, and vice-versa. This indicates umami synergistic mixtures are perceived as having a sweet, or at least sucrose-like, taste to mice. Considering other recent studies, our data argue strongly in favor of multiple receptor mechanisms for umami detection, and complexity in taste perception models for rodents.
先前的电生理研究表明，被人类归类为鲜味的化合物组合，如谷氨酸盐和5'-核糖核苷酸，在整个啮齿动物味觉系统的神经元中引发协同反应，并产生一种类似于对甜味化合物反应的模式。当前的研究检验了这样一个假设，即谷氨酸一钾（MPG）和肌醇单磷酸（IMP）的协同混合物在小鼠中与蔗糖具有感知相似性。我们使用一系列条件性味觉厌恶（CTA）测试来估计这些味觉物质与单个鲜味化合物之间的行为相似性，该测试程序用于测量对一种刺激形成的CTA是否会泛化到另一种刺激。我们的主要发现是，对MPG + IMP协同混合物形成的CTA会泛化到蔗糖，反之亦然。这表明鲜味协同混合物在小鼠看来具有甜味，或至少具有类似蔗糖的味道。结合其他近期研究，我们的数据有力地支持了鲜味检测的多种受体机制以及啮齿动物味觉感知模型的复杂性。
