Department of Mechanical Engineering, Iowa State University, Ames, IA, 50011, USA.
Center for Advanced Host Defense Immunobiotics and Translational Comparative Medicine, Iowa State University, Ames, IA, 50011, USA.
Adv Healthc Mater. 2015 Jul 15;4(10):1426-50. doi: 10.1002/adhm.201500040. Epub 2015 Mar 26.
In recent years, the exploitation of phenomena surrounding microfluidics has seen an increase in popularity, as researchers have found a way to use their unique properties to create superior design alternatives. One such application is representing the properties and functions of different organs on a microscale chip for the purpose of drug testing or tissue engineering. With the introduction of "organ-on-a-chip" systems, researchers have proposed various methods on various organ-on-a-chip systems to mimic their in vivo counterparts. In this article, a systematic approach is taken to review current technologies pertaining to organ-on-a-chip systems. Design processes with attention to the particular instruments, cells, and materials used are presented.
近年来，人们越来越关注微流控现象的开发，研究人员发现可以利用其独特的性质来创造更好的设计方案。其中一种应用是在微芯片上模拟不同器官的特性和功能，用于药物测试或组织工程。随着“芯片上器官”系统的引入，研究人员已经在各种“芯片上器官”系统上提出了各种模拟其体内对应物的方法。在本文中，我们采取系统的方法来回顾当前与“芯片上器官”系统相关的技术。介绍了特别关注所使用的特定仪器、细胞和材料的设计过程。
