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生物相容性材料的表面变形：生物应用的最新进展

Surface Deformation of Biocompatible Materials: Recent Advances in Biological Applications.

作者信息

Yoon Sunhee, Fuwad Ahmed, Jeong Seorin, Cho Hyeran, Jeon Tae-Joon, Kim Sun Min

机构信息

Department of Biological Sciences and Bioengineering, Inha University, 100, Inha-ro, Michuhol-gu, Incheon 22212, Republic of Korea.

Industry-Academia Interactive R&E Center for Bioprocess Innovation (BK21), Inha University, 100, Inha-ro, Michuhol-gu, Incheon 22212, Republic of Korea.

出版信息

Biomimetics (Basel). 2024 Jun 28;9(7):395. doi: 10.3390/biomimetics9070395.

DOI:10.3390/biomimetics9070395
PMID:39056836
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11274418/
Abstract

The surface topography of substrates is a crucial factor that determines the interaction with biological materials in bioengineering research. Therefore, it is important to appropriately modify the surface topography according to the research purpose. Surface topography can be fabricated in various forms, such as wrinkles, creases, and ridges using surface deformation techniques, which can contribute to the performance enhancement of cell chips, organ chips, and biosensors. This review provides a comprehensive overview of the characteristics of soft, hard, and hybrid substrates used in the bioengineering field and the surface deformation techniques applied to the substrates. Furthermore, this review summarizes the cases of cell-based research and other applications, such as biosensor research, that utilize surface deformation techniques. In cell-based research, various studies have reported optimized cell behavior and differentiation through surface deformation, while, in the biosensor and biofilm fields, performance improvement cases due to surface deformation have been reported. Through these studies, we confirm the contribution of surface deformation techniques to the advancement of the bioengineering field. In the future, it is expected that the application of surface deformation techniques to the real-time interaction analysis between biological materials and dynamically deformable substrates will increase the utilization and importance of these techniques in various fields, including cell research and biosensors.

摘要

在生物工程研究中，基底的表面形貌是决定与生物材料相互作用的关键因素。因此，根据研究目的适当地改变表面形貌很重要。表面形貌可以通过表面变形技术以各种形式制造，如皱纹、折痕和脊状，这有助于提高细胞芯片、器官芯片和生物传感器的性能。本文综述了生物工程领域中使用的软质、硬质和混合基底的特性以及应用于这些基底的表面变形技术。此外，本文还总结了利用表面变形技术进行的基于细胞的研究以及其他应用案例，如生物传感器研究。在基于细胞的研究中，各种研究报告了通过表面变形优化细胞行为和分化，而在生物传感器和生物膜领域，也有因表面变形而提高性能的案例报告。通过这些研究，我们证实了表面变形技术对生物工程领域发展的贡献。未来，预计表面变形技术在生物材料与动态可变形基底之间实时相互作用分析中的应用，将提高这些技术在包括细胞研究和生物传感器在内的各个领域的利用率和重要性。

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