Lechowicz Justyna, Krawczyk-Balska Agata
Department of Applied Microbiology, Faculty of Biology, University of Warsaw, Miecznikowa 1, 02-096, Warsaw, Poland.
Biometals. 2015 Aug;28(4):587-603. doi: 10.1007/s10534-015-9849-5. Epub 2015 Mar 28.
Listeria monocytogenes is a Gram-positive bacterium that causes a rare but severe human disease with high mortality rate. The microorganism is widespread in the natural environment where it shows a saprophytic lifestyle. In the human body it infects many different cell types, where it lives intracellularly, however it may also temporarily live extracellularly. The ability to survive and grow in such diverse niches suggests that this bacterium has a wide range of mechanisms for both the acquisition of various sources of iron and effective management of this microelement. In this review, data about the mechanisms of transport, metabolism and regulation of iron, including recent findings in these areas, are summarized with focus on the importance of these mechanisms for the virulence of L. monocytogenes. These data indicate the key role of haem transport and maintenance of intracellular iron homeostasis for the pathogenesis of L. monocytogenes. Furthermore, some of the proteins involved in iron homeostasis like Fri and FrvA seem to deserve special attention due to their potential use in the development of new therapeutic antilisterial strategies.
单核细胞增生李斯特菌是一种革兰氏阳性细菌，可引发一种罕见但严重的人类疾病，死亡率很高。这种微生物在自然环境中广泛存在，呈现腐生生活方式。在人体中，它会感染许多不同的细胞类型，并在细胞内生存，但也可能暂时在细胞外生存。能够在如此多样的生态位中存活和生长，表明这种细菌具有广泛的机制来获取各种铁源并有效管理这种微量元素。在这篇综述中，总结了关于铁的运输、代谢和调节机制的数据，包括这些领域的最新发现，重点是这些机制对单核细胞增生李斯特菌毒力的重要性。这些数据表明血红素运输和维持细胞内铁稳态对单核细胞增生李斯特菌发病机制的关键作用。此外，一些参与铁稳态的蛋白质，如Fri和FrvA，由于它们在开发新的抗李斯特菌治疗策略中的潜在用途，似乎值得特别关注。
