Krawczyk-Balska Agata, Ładziak Magdalena, Burmistrz Michał, Ścibek Katarzyna, Kallipolitis Birgitte H
Department of Molecular Microbiology, Biological and Chemical Research Centre, Faculty of Biology, University of Warsaw, Warsaw, Poland.
Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.
Front Microbiol. 2021 Apr 14;12:622829. doi: 10.3389/fmicb.2021.622829. eCollection 2021.
is an intracellular pathogen that is well known for its adaptability to life in a broad spectrum of different niches. RNA-mediated regulatory mechanisms in play important roles in successful adaptation providing fast and versatile responses to a changing environment. Recent findings indicate that non-coding RNAs (ncRNAs) regulate a variety of processes in this bacterium, such as environmental sensing, metabolism and virulence, as well as immune responses in eukaryotic cells. In this review, the current knowledge on RNA-mediated regulation in is presented, with special focus on the roles and mechanisms underlying modulation of metabolism and virulence. Collectively, these findings point to ncRNAs as important gene regulatory elements in , both outside and inside an infected host. However, the involvement of regulatory ncRNAs in bacterial physiology and virulence is still underestimated and probably will be better assessed in the coming years, especially in relation to discovering the regulatory functions of 5' and 3' untranslated regions and excludons, and by exploring the role of ncRNAs in interaction with both bacterial and host proteins.
是一种细胞内病原体，以其对广泛不同生态位中生存的适应性而闻名。其RNA介导的调控机制在成功适应过程中发挥重要作用，能对不断变化的环境提供快速且多样的反应。最近的研究结果表明，非编码RNA（ncRNAs）在这种细菌中调节多种过程，如环境感知、代谢和毒力，以及真核细胞中的免疫反应。在这篇综述中，介绍了关于RNA介导的调控的当前知识，特别关注代谢和毒力调节背后的作用和机制。总的来说，这些发现表明ncRNAs是该病原体在感染宿主内外的重要基因调控元件。然而，调控性ncRNAs在细菌生理学和毒力中的作用仍被低估，未来几年可能会得到更好的评估，特别是在发现5'和3'非翻译区及排除子的调控功能，以及探索ncRNAs在与细菌和宿主蛋白相互作用中的作用方面。
