用于药物递送的酯酶和pH响应性聚（β-氨基酯）封端的介孔二氧化硅纳米颗粒
Esterase- and pH-responsive poly(β-amino ester)-capped mesoporous silica nanoparticles for drug delivery.
作者信息
Fernando Isurika R, Ferris Daniel P, Frasconi Marco, Malin Dmitry, Strekalova Elena, Yilmaz M Deniz, Ambrogio Michael W, Algaradah Mohammed M, Hong Michael P, Chen Xinqi, Nassar Majed S, Botros Youssry Y, Cryns Vincent L, Stoddart J Fraser
机构信息
Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208, USA.
出版信息
Nanoscale. 2015 Apr 28;7(16):7178-83. doi: 10.1039/c4nr07443b.
Gating of mesoporous silica nanoparticles (MSNs) with the stimuli-responsive poly(β-amino ester) has been achieved. This hybrid nanocarrier releases doxorubicin (DOX) under acidic conditions or in the presence of porcine liver esterase. The DOX loaded poly(β-amino ester)-capped MSNs reduce cell viability when tested on MDA-MB-231 human breast cancer cells.
已经实现了用刺激响应性聚（β-氨基酯）对介孔二氧化硅纳米颗粒（MSN）进行门控。这种杂化纳米载体在酸性条件下或在猪肝酯酶存在时释放阿霉素（DOX）。在MDA-MB-231人乳腺癌细胞上进行测试时，负载DOX的聚（β-氨基酯）封端的MSN会降低细胞活力。
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