Hatten Kyle M, Palmer James N, Lee Robert J, Adappa Nithin D, Kennedy David W, Cohen Noam A
Department of Otorhinolaryngology-Head & Neck Surgery, University of Pennsylvania Health System, Philadelphia, Pennsylvania, USA
Department of Otorhinolaryngology-Head & Neck Surgery, University of Pennsylvania Health System, Philadelphia, Pennsylvania, USA.
Otolaryngol Head Neck Surg. 2015 Jun;152(6):1140-4. doi: 10.1177/0194599815577567. Epub 2015 Mar 27.
To evaluate nasal mucus glucose concentrations in patients with and without chronic rhinosinusitis and determine if corticosteroid therapy alters mucus glucose.
Prospective observational study.
Single tertiary care center.
Ninety-five patients presenting to an otolaryngology clinic.
Participants completed questionnaires that included a history of medical and surgical therapies as well as sinusitis-specific quality-of-life measurements. Nasal mucus was collected in an outpatient clinic using an open cell foam technique. The nasal mucus glucose concentrations of patients with and without chronic rhinosinusitis were compared to the use of systemic and topical glucocorticoid treatment.
A statistically significant difference was measured between mean nasal glucose secretions of control patients, 10.2 mg/dL, compared with patients diagnosed with chronic rhinosinusitis, 18.4 mg/dL (P < .0001). Use of corticosteroids, both topical and systemic, did not correlate with nasal glucose concentrations.
Patients diagnosed with chronic rhinosinusitis have elevated nasal glucose concentrations compared with control patients, and this elevated nasal glucose level was independent of corticosteroid use. Nasal glucose may independently contribute to the pathophysiology of chronic rhinosinusitis.
评估慢性鼻-鼻窦炎患者与非慢性鼻-鼻窦炎患者的鼻腔黏液葡萄糖浓度，并确定皮质类固醇治疗是否会改变黏液葡萄糖水平。
前瞻性观察性研究。
单一的三级医疗中心。
95名前往耳鼻喉科门诊的患者。
参与者完成问卷调查，内容包括药物和手术治疗史以及鼻窦炎特异性生活质量测量。在门诊使用开孔泡沫技术收集鼻腔黏液。比较慢性鼻-鼻窦炎患者与非慢性鼻-鼻窦炎患者的鼻腔黏液葡萄糖浓度，以及全身和局部糖皮质激素治疗的使用情况。
对照患者的平均鼻腔葡萄糖分泌量为10.2mg/dL，与诊断为慢性鼻-鼻窦炎的患者（18.4mg/dL）相比，差异具有统计学意义（P <.0001）。局部和全身使用皮质类固醇与鼻腔葡萄糖浓度均无相关性。
与对照患者相比，诊断为慢性鼻-鼻窦炎的患者鼻腔葡萄糖浓度升高，且这种鼻腔葡萄糖水平升高与皮质类固醇的使用无关。鼻腔葡萄糖可能独立地参与慢性鼻-鼻窦炎的病理生理过程。
