Center for Microbial Ecology and Technology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B-9000, Ghent, Belgium.
Research Group of Environmental Ecology and Applied Microbiology, Department of Bioscience Engineering, University of Antwerp, Groenenborgerlaan 171, 2020, Antwerp, Belgium.
Microbiome. 2018 Apr 24;6(1):75. doi: 10.1186/s40168-018-0462-z.
Chronic rhinosinusitis (CRS) is a chronic inflammation of the mucosa of the nose and paranasal sinuses affecting approximately 11% of the adult population in Europe. Inadequate immune responses, as well as a dysbiosis of the sinonasal microbiota, have been put forward as aetiological factors of the disease. However, despite the prevalence of this disease, there is no consensus on the aetiology and mechanisms of pathogenesis of CRS. Further research requires in vitro models mimicking the healthy and diseased host environment along with the sinonasal microbiota. This review aims to provide an overview of CRS model systems and proposes in vitro modelling strategies to conduct mechanistic research in an ecological framework on the sinonasal microbiota and its interactions with the host in health and CRS.
慢性鼻-鼻窦炎（CRS）是一种鼻腔和鼻旁窦黏膜的慢性炎症，影响了欧洲约 11%的成年人群。免疫应答不足以及鼻窦微生物群落的失调被认为是该疾病的病因。然而，尽管这种疾病很普遍，但对于 CRS 的病因和发病机制仍没有共识。进一步的研究需要模拟健康和患病宿主环境以及鼻窦微生物群落的体外模型。本综述旨在概述 CRS 模型系统，并提出体外建模策略，以便在生态框架内对鼻窦微生物群落及其在健康和 CRS 中与宿主的相互作用进行机制研究。
