中风与神经保护中的非编码RNA
Non-Coding RNAs in Stroke and Neuroprotection.
作者信息
Saugstad Julie A
机构信息
Department of Anesthesiology and Perioperative Medicine, Oregon Health & Science University , Portland, OR , USA.
出版信息
Front Neurol. 2015 Mar 13;6:50. doi: 10.3389/fneur.2015.00050. eCollection 2015.
This review will focus on the current state of knowledge regarding non-coding RNAs (ncRNA) in stroke and neuroprotection. There will be a brief introduction to microRNAs (miRNA), long ncRNAs (lncRNA), and piwi-interacting RNAs (piRNA), followed by evidence for the regulation of ncRNAs in ischemia. This review will also discuss the effect of neuroprotection induced by a sublethal duration of ischemia or other stimuli given before a stroke (preconditioning) on miRNA expression and the role of miRNAs in preconditioning-induced neuroprotection. Experimental manipulation of miRNAs and/or their targets to induce pre- or post-stroke protection will also be presented, as well as discussion on miRNA responses to current post-stroke therapies. This review will conclude with a brief discussion of future directions for ncRNAs studies in stroke, such as new approaches to model complex ncRNA datasets, challenges in ncRNA studies, and the impact of extracellular RNAs on human diseases such as stroke.
本综述将聚焦于中风与神经保护方面非编码RNA（ncRNA）的当前知识状态。将对微小RNA（miRNA）、长链非编码RNA（lncRNA）和与Piwi蛋白相互作用的RNA（piRNA）进行简要介绍，随后阐述ncRNA在缺血中的调控证据。本综述还将讨论短暂缺血持续时间或中风前给予的其他刺激（预处理）所诱导的神经保护对miRNA表达的影响，以及miRNA在预处理诱导的神经保护中的作用。还将介绍对miRNA及其靶标进行实验性操作以诱导中风前或中风后保护，以及对miRNA对当前中风后治疗反应的讨论。本综述将以对中风中ncRNA研究未来方向的简要讨论作为结尾，例如对复杂ncRNA数据集进行建模的新方法、ncRNA研究中的挑战，以及细胞外RNA对诸如中风等人类疾病的影响。
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