Department of Biology, Tehran North Branch, Islamic Azad University, Tehran, Iran.
Immunology Department, Medical School, Shiraz University of Medical Sciences, Shiraz, Iran.
Metab Brain Dis. 2020 Jan;35(1):31-43. doi: 10.1007/s11011-019-00485-2. Epub 2019 Aug 24.
Stroke is the leading cause of death and physical disability worldwide. Non-coding RNAs (ncRNAs) are endogenous molecules that play key roles in the pathophysiology and retrieval processes following ischemic stroke. The potential of ncRNAs, especially microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) in neuroprotection and angiogenesis highlights their potential as targets for therapeutic intervention. In this review, we document the miRNAs and lncRNAs that have been reported to exert regulatory actions in neuroprotective and angiogenic processes through different mechanisms involving their interaction with target coding genes. We believe that exploration of the expression profiles and the possible functions of ncRNAs during the recovery processes will help comprehension of the molecular mechanisms responsible for neuroprotection and angiogenesis, and may also contribute to find biomarkers and targets for future stroke intervention.
脑卒中是全球范围内导致死亡和身体残疾的主要原因。非编码 RNA（ncRNA）是内源性分子，在缺血性脑卒中后的病理生理学和恢复过程中发挥关键作用。ncRNA，特别是 microRNA（miRNA）和长非编码 RNA（lncRNA）在神经保护和血管生成方面的潜力突出了它们作为治疗干预靶点的潜力。在这篇综述中，我们记录了已经报道的 miRNA 和 lncRNA，它们通过不同的机制发挥调节作用，包括与靶编码基因的相互作用，从而在神经保护和血管生成过程中发挥作用。我们相信，在恢复过程中探索 ncRNA 的表达谱和可能的功能将有助于理解负责神经保护和血管生成的分子机制，也可能有助于找到未来脑卒中干预的生物标志物和靶点。
